Abstract
Background:We investigated the impact of follow-up duration to determine whether two immunohistochemical prognostic panels, IHC4 and Mammostrat, provide information on the risk of early or late distant recurrence using the Edinburgh Breast Conservation Series and the Tamoxifen vs Exemestane Adjuvant Multinational (TEAM) trial.Methods:The multivariable fractional polynomial time (MFPT) algorithm was used to determine which variables had possible non-proportional effects. The performance of the scores was assessed at various lengths of follow-up and Cox regression modelling was performed over the intervals of 0-5 years and >5 years.Results:We observed a strong time dependence of both the IHC4 and Mammostrat scores, with their effects decreasing over time. In the first 5 years of follow-up only, the addition of both scores to clinical factors provided statistically significant information (P
Original language | English |
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Pages (from-to) | 2242-2247 |
Number of pages | 6 |
Journal | British Journal of Cancer |
Volume | 111 |
Issue number | 12 |
DOIs | |
Publication status | Published - 9 Dec 2014 |
Keywords
- biomarkers
- breast cancer
- relapse risk
- time dependency
ASJC Scopus subject areas
- Cancer Research
- Oncology