Thermosensitive hydrogel as an in situ gelling antimicrobial ocular dressing

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Thermosensitive hydrogel as an in situ gelling antimicrobial ocular dressing. / Mohammed, Sameed; Chouhan, Gurpreet; Anuforom, Olachi; Cooke, Megan; Walsh, Anna; Morgan-Warren, Peter; Jenkins, Michael; De Cogan, Felicity.

In: Materials Science and Engineering C, Vol. 78, 01.09.2017, p. 203-209.

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@article{02013f7d25a44274b62383993e96329c,
title = "Thermosensitive hydrogel as an in situ gelling antimicrobial ocular dressing",
abstract = "Microbial keratitis is a severe ocular condition and one of the most prevalent causes of corneal scarring and associated blindness worldwide. Risk factors include contact lens use, ocular trauma, ocular surface disease and immunosuppression. Initial clinical management mandates intensive (hourly or more frequent) topical administration of broad spectrum antimicrobial therapy for at least 48 h, which may require hospital admission, followed by tailored therapy based on microbiological investigation and the institution of strategies to reduce inflammation and promote healing. In this work we report an ocular wound dressing which can encapsulate and give sustained release of different antibiotics. The use of this dressing would allow patients to have eye dropson a 4 hourly basis, thereby facilitating treatment compliance and reducing hospital admissions.",
keywords = "Wound dressing, Hydrogel, Antibiotic delivery, Ocular drug delivery",
author = "Sameed Mohammed and Gurpreet Chouhan and Olachi Anuforom and Megan Cooke and Anna Walsh and Peter Morgan-Warren and Michael Jenkins and {De Cogan}, Felicity",
year = "2017",
month = sep,
day = "1",
doi = "10.1016/j.msec.2017.04.065",
language = "English",
volume = "78",
pages = "203--209",
journal = "Materials Science and Engineering C",
issn = "0928-4931",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Thermosensitive hydrogel as an in situ gelling antimicrobial ocular dressing

AU - Mohammed, Sameed

AU - Chouhan, Gurpreet

AU - Anuforom, Olachi

AU - Cooke, Megan

AU - Walsh, Anna

AU - Morgan-Warren, Peter

AU - Jenkins, Michael

AU - De Cogan, Felicity

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Microbial keratitis is a severe ocular condition and one of the most prevalent causes of corneal scarring and associated blindness worldwide. Risk factors include contact lens use, ocular trauma, ocular surface disease and immunosuppression. Initial clinical management mandates intensive (hourly or more frequent) topical administration of broad spectrum antimicrobial therapy for at least 48 h, which may require hospital admission, followed by tailored therapy based on microbiological investigation and the institution of strategies to reduce inflammation and promote healing. In this work we report an ocular wound dressing which can encapsulate and give sustained release of different antibiotics. The use of this dressing would allow patients to have eye dropson a 4 hourly basis, thereby facilitating treatment compliance and reducing hospital admissions.

AB - Microbial keratitis is a severe ocular condition and one of the most prevalent causes of corneal scarring and associated blindness worldwide. Risk factors include contact lens use, ocular trauma, ocular surface disease and immunosuppression. Initial clinical management mandates intensive (hourly or more frequent) topical administration of broad spectrum antimicrobial therapy for at least 48 h, which may require hospital admission, followed by tailored therapy based on microbiological investigation and the institution of strategies to reduce inflammation and promote healing. In this work we report an ocular wound dressing which can encapsulate and give sustained release of different antibiotics. The use of this dressing would allow patients to have eye dropson a 4 hourly basis, thereby facilitating treatment compliance and reducing hospital admissions.

KW - Wound dressing

KW - Hydrogel

KW - Antibiotic delivery

KW - Ocular drug delivery

U2 - 10.1016/j.msec.2017.04.065

DO - 10.1016/j.msec.2017.04.065

M3 - Article

VL - 78

SP - 203

EP - 209

JO - Materials Science and Engineering C

JF - Materials Science and Engineering C

SN - 0928-4931

ER -