Thermosensitive hydrogel as an in situ gelling antimicrobial ocular dressing

Research output: Contribution to journalArticle

Authors

  • Sameed Mohammed
  • Olachi Anuforom
  • Anna Walsh
  • Peter Morgan-Warren

Abstract

Microbial keratitis is a severe ocular condition and one of the most prevalent causes of corneal scarring and associated blindness worldwide. Risk factors include contact lens use, ocular trauma, ocular surface disease and immunosuppression. Initial clinical management mandates intensive (hourly or more frequent) topical administration of broad spectrum antimicrobial therapy for at least 48 h, which may require hospital admission, followed by tailored therapy based on microbiological investigation and the institution of strategies to reduce inflammation and promote healing. In this work we report an ocular wound dressing which can encapsulate and give sustained release of different antibiotics. The use of this dressing would allow patients to have eye drops
on a 4 hourly basis, thereby facilitating treatment compliance and reducing hospital admissions.

Details

Original languageEnglish
Pages (from-to)203-209
Number of pages7
JournalMaterials Science and Engineering C
Volume78
Early online date12 Apr 2017
Publication statusPublished - 1 Sep 2017

Keywords

  • Wound dressing, Hydrogel, Antibiotic delivery, Ocular drug delivery