Abstract
Primary Sjögren's syndrome (pSS) is a complex autoimmune disease characterised by local exocrine glandular involvement and systemic multiorgan manifestations. In this review we will discuss the value of the histological examination of the salivary glands in the classification criteria, and more recently as prognostic tool for patient stratification and monitoring. The limitations of the current tools used to assess salivary gland pathology in pSS will also be reviewed in relation to using salivary gland biopsy analysis as an outcome measure in clinical trials.
Original language | English |
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Article number | w14168 |
Number of pages | 11 |
Journal | Swiss medical weekly |
Volume | 145 |
DOIs | |
Publication status | Published - 7 Sept 2015 |
Keywords
- Biopsy
- Humans
- Predictive Value of Tests
- Prognosis
- Salivary Glands
- Sjogren's Syndrome
- salivary gland biopsy
- histology
- germinal centers
- biologics
- outcome measures