The utility of routine surveillance screening with magnetic resonance imaging (MRI) to detect tumour recurrence in children with low-grade central nervous system (CNS) tumours: a systematic review

Research output: Contribution to journalArticle

Authors

  • Simon Bailey
  • Barry Pizer
  • Martin English
  • Robert Phillips
  • Shivaram Avula
  • Sophie Wilne
  • Jayne Wilson

Abstract

Background: Magnetic resonance imaging (MRI) is routinely used as a surveillance tool to detect early asymptomatic tumour recurrence with a view to improving patient outcomes. This systematic review aimed to assess its utility in children with low-grade CNS tumours.

Methods: Using standard systematic review methods, twelve databases were searched up to January 2017.

Results: Seven retrospective case series studies (n = 370 patients) were included, with average follow-up ranging from 5.6 to 7 years. No randomised controlled trials (RCTs) were identified. Due to study heterogeneity only a descriptive synthesis could be undertaken. Imaging was most frequent in the first year post-surgery (with 2–4 scans) reducing to around half this frequency in year two and annually thereafter for the duration of follow-up. Diagnostic yield ranged from 0.25 to 2%. Recurrence rates ranged from 5 to 41%, with most recurrences asymptomatic (range 65–100%). Collectively, 56% of recurrences had occurred within the first year post-treatment (46% in the first 6-months), 68% by year two and 90% by year five. Following recurrence, 90% of patients underwent treatment changes, mainly repeat surgery (72%). Five-year OS ranged from 96 to 100%, while five-year recurrence-free survival ranged from 67 to 100%. None of the studies reported quality of life measures.

Conclusion: This systematic review highlights the paucity of evidence currently available to assess the utility of MRI surveillance despite it being routine clinical practice and costly to patients, their families and healthcare systems. This needs to be evaluated within the context of an RCT.

Details

Original languageEnglish
Pages (from-to)507-522
JournalJournal of Neuro-Oncology
Volume139
Issue number3
Early online date9 Jun 2018
Publication statusPublished - 1 Sep 2018

Keywords

  • Systematic review, Magnetic resonance imaging (MRI), Surveillance, Children, Central nervous system (CNS) tumours, Recurrence, Pilocytic astrocytoma, Low grade glioma