The two faces of BRCA2, a FANCtastic discovery

Grant Stewart; SJ Elledge

doi:10.1016/S1097-2765(02)00580-4

The two faces of BRCA2, a FANCtastic discovery

Grant Stewart, SJ Elledge

Cancer and Genomic Sciences

Research output: Contribution to journal › Article

28 Citations (Scopus)

Abstract

The molecular defects responsible for the cancer predisposition syndrome Fanconi's Anemia (FA) have been elusive. A recent study reports that the FANC-B and -D1 subgroups result from hypomorphic mutations in BRCA2. Given that BRCA2 protein participates in homologous recombination, this finding connects at least a subset of the FA phenotypes to defective DNA repair.

Original language	English
Pages (from-to)	2-4
Number of pages	3
Journal	Molecular Cell
Volume	10
DOIs	https://doi.org/10.1016/S1097-2765(02)00580-4
Publication status	Published - 1 Jul 2002

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S1097-2765(02)00580-4

Cite this

@article{76d034beda3449da92f8e8dfe6f88098,

title = "The two faces of BRCA2, a FANCtastic discovery",

abstract = "The molecular defects responsible for the cancer predisposition syndrome Fanconi's Anemia (FA) have been elusive. A recent study reports that the FANC-B and -D1 subgroups result from hypomorphic mutations in BRCA2. Given that BRCA2 protein participates in homologous recombination, this finding connects at least a subset of the FA phenotypes to defective DNA repair.",

author = "Grant Stewart and SJ Elledge",

year = "2002",

month = jul,

day = "1",

doi = "10.1016/S1097-2765(02)00580-4",

language = "English",

volume = "10",

pages = "2--4",

journal = "Molecular Cell",

publisher = "Elsevier",

}

TY - JOUR

T1 - The two faces of BRCA2, a FANCtastic discovery

AU - Stewart, Grant

AU - Elledge, SJ

PY - 2002/7/1

Y1 - 2002/7/1

N2 - The molecular defects responsible for the cancer predisposition syndrome Fanconi's Anemia (FA) have been elusive. A recent study reports that the FANC-B and -D1 subgroups result from hypomorphic mutations in BRCA2. Given that BRCA2 protein participates in homologous recombination, this finding connects at least a subset of the FA phenotypes to defective DNA repair.

AB - The molecular defects responsible for the cancer predisposition syndrome Fanconi's Anemia (FA) have been elusive. A recent study reports that the FANC-B and -D1 subgroups result from hypomorphic mutations in BRCA2. Given that BRCA2 protein participates in homologous recombination, this finding connects at least a subset of the FA phenotypes to defective DNA repair.

UR - http://www.scopus.com/inward/record.url?scp=0036342368&partnerID=8YFLogxK

U2 - 10.1016/S1097-2765(02)00580-4

DO - 10.1016/S1097-2765(02)00580-4

M3 - Article

C2 - 12150898

VL - 10

SP - 2

EP - 4

JO - Molecular Cell

JF - Molecular Cell

ER -

The two faces of BRCA2, a FANCtastic discovery

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this