The Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand and Lung Cancer Still Following the Right TRAIL?

Research output: Contribution to journalEditorial


Colleges, School and Institutes


Tumor necrosis factor-related apoptosis-inducing ligand is a type II membrane-bound protein whose C-terminal extracellular domain shows clear homology to other tumor necrosis factor family members. It is constitutively expressed on macrophages, T cells, natural killer cells, and dendritic cells and selectively kills transformed cells leaving most of the normal cells alone. This selectivity has led to great interest in it use as a therapeutic agent for the treatment of malignancy. In this review, this critical pathway is described, highlighting its mechanistic manipulation for therapeutic benefit and the recent phase I and II trials in lung cancer that have been performed or are currently ongoing are also discussed.


Original languageEnglish
Pages (from-to)983-987
Number of pages5
JournalJournal of Thoracic Oncology
Issue number6
Publication statusPublished - 1 Jun 2011


  • Small cell lung cancer, Non-small cell lung cancer, Apoptosis, TNF-related apoptosis-inducing ligand (TRAIL), Clinical trials

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