The Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand and Lung Cancer Still Following the Right TRAIL?
Research output: Contribution to journal › Editorial
Colleges, School and Institutes
Tumor necrosis factor-related apoptosis-inducing ligand is a type II membrane-bound protein whose C-terminal extracellular domain shows clear homology to other tumor necrosis factor family members. It is constitutively expressed on macrophages, T cells, natural killer cells, and dendritic cells and selectively kills transformed cells leaving most of the normal cells alone. This selectivity has led to great interest in it use as a therapeutic agent for the treatment of malignancy. In this review, this critical pathway is described, highlighting its mechanistic manipulation for therapeutic benefit and the recent phase I and II trials in lung cancer that have been performed or are currently ongoing are also discussed.
|Number of pages||5|
|Journal||Journal of Thoracic Oncology|
|Publication status||Published - 1 Jun 2011|
- Small cell lung cancer, Non-small cell lung cancer, Apoptosis, TNF-related apoptosis-inducing ligand (TRAIL), Clinical trials