The transcriptional landscape of polyploid wheat

Research output: Contribution to journalArticle

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The transcriptional landscape of polyploid wheat. / Borrill, P; International Wheat Genome Sequencing Consortium (IWGSC).

In: Science, Vol. 361, No. 6403, eaar6089, 17.08.2018.

Research output: Contribution to journalArticle

Harvard

Borrill, P & International Wheat Genome Sequencing Consortium (IWGSC) 2018, 'The transcriptional landscape of polyploid wheat', Science, vol. 361, no. 6403, eaar6089. https://doi.org/10.1126/science.aar6089

APA

Borrill, P., & International Wheat Genome Sequencing Consortium (IWGSC) (2018). The transcriptional landscape of polyploid wheat. Science, 361(6403), [eaar6089]. https://doi.org/10.1126/science.aar6089

Vancouver

Borrill P, International Wheat Genome Sequencing Consortium (IWGSC). The transcriptional landscape of polyploid wheat. Science. 2018 Aug 17;361(6403). eaar6089. https://doi.org/10.1126/science.aar6089

Author

Borrill, P ; International Wheat Genome Sequencing Consortium (IWGSC). / The transcriptional landscape of polyploid wheat. In: Science. 2018 ; Vol. 361, No. 6403.

Bibtex

@article{061ad11c1e2244d9adf49f27d2182e27,
title = "The transcriptional landscape of polyploid wheat",
abstract = "The coordinated expression of highly related homoeologous genes in polyploid species underlies the phenotypes of many of the world's major crops. Here we combine extensive gene expression datasets to produce a comprehensive, genome-wide analysis of homoeolog expression patterns in hexaploid bread wheat. Bias in homoeolog expression varies between tissues, with ~30% of wheat homoeologs showing nonbalanced expression. We found expression asymmetries along wheat chromosomes, with homoeologs showing the largest inter-tissue, inter-cultivar, and coding sequence variation, most often located in high-recombination distal ends of chromosomes. These transcriptionally dynamic genes potentially represent the first steps toward neo- or subfunctionalization of wheat homoeologs. Coexpression networks reveal extensive coordination of homoeologs throughout development and, alongside a detailed expression atlas, provide a framework to target candidate genes underpinning agronomic traits in wheat.",
keywords = "Bread, Gene Expression Profiling, Gene Expression Regulation, Developmental, Gene Expression Regulation, Plant, Genome, Plant, Polyploidy, RNA, Plant/genetics, Sequence Analysis, RNA, Transcription, Genetic, Triticum/genetics",
author = "Ram{\'i}rez-Gonz{\'a}lez, {R H} and P Borrill and D Lang and Harrington, {S A} and J Brinton and L Venturini and M Davey and J Jacobs and {van Ex}, F and A Pasha and Y Khedikar and Robinson, {S J} and Cory, {A T} and T Florio and L Concia and C Juery and H Schoonbeek and B Steuernagel and D Xiang and Ridout, {C J} and B Chalhoub and Mayer, {K F X} and M Benhamed and D Latrasse and A Bendahmane and {International Wheat Genome Sequencing Consortium (IWGSC)} and Wulff, {B B H} and R Appels and V Tiwari and R Datla and F Choulet and Pozniak, {C J} and Provart, {N J} and E Paux and M Spannagl and A Br{\"a}utigam and C Uauy",
note = "Copyright {\textcopyright} 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.",
year = "2018",
month = aug,
day = "17",
doi = "10.1126/science.aar6089",
language = "English",
volume = "361",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6403",

}

RIS

TY - JOUR

T1 - The transcriptional landscape of polyploid wheat

AU - Ramírez-González, R H

AU - Borrill, P

AU - Lang, D

AU - Harrington, S A

AU - Brinton, J

AU - Venturini, L

AU - Davey, M

AU - Jacobs, J

AU - van Ex, F

AU - Pasha, A

AU - Khedikar, Y

AU - Robinson, S J

AU - Cory, A T

AU - Florio, T

AU - Concia, L

AU - Juery, C

AU - Schoonbeek, H

AU - Steuernagel, B

AU - Xiang, D

AU - Ridout, C J

AU - Chalhoub, B

AU - Mayer, K F X

AU - Benhamed, M

AU - Latrasse, D

AU - Bendahmane, A

AU - International Wheat Genome Sequencing Consortium (IWGSC)

AU - Wulff, B B H

AU - Appels, R

AU - Tiwari, V

AU - Datla, R

AU - Choulet, F

AU - Pozniak, C J

AU - Provart, N J

AU - Paux, E

AU - Spannagl, M

AU - Bräutigam, A

AU - Uauy, C

N1 - Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

PY - 2018/8/17

Y1 - 2018/8/17

N2 - The coordinated expression of highly related homoeologous genes in polyploid species underlies the phenotypes of many of the world's major crops. Here we combine extensive gene expression datasets to produce a comprehensive, genome-wide analysis of homoeolog expression patterns in hexaploid bread wheat. Bias in homoeolog expression varies between tissues, with ~30% of wheat homoeologs showing nonbalanced expression. We found expression asymmetries along wheat chromosomes, with homoeologs showing the largest inter-tissue, inter-cultivar, and coding sequence variation, most often located in high-recombination distal ends of chromosomes. These transcriptionally dynamic genes potentially represent the first steps toward neo- or subfunctionalization of wheat homoeologs. Coexpression networks reveal extensive coordination of homoeologs throughout development and, alongside a detailed expression atlas, provide a framework to target candidate genes underpinning agronomic traits in wheat.

AB - The coordinated expression of highly related homoeologous genes in polyploid species underlies the phenotypes of many of the world's major crops. Here we combine extensive gene expression datasets to produce a comprehensive, genome-wide analysis of homoeolog expression patterns in hexaploid bread wheat. Bias in homoeolog expression varies between tissues, with ~30% of wheat homoeologs showing nonbalanced expression. We found expression asymmetries along wheat chromosomes, with homoeologs showing the largest inter-tissue, inter-cultivar, and coding sequence variation, most often located in high-recombination distal ends of chromosomes. These transcriptionally dynamic genes potentially represent the first steps toward neo- or subfunctionalization of wheat homoeologs. Coexpression networks reveal extensive coordination of homoeologs throughout development and, alongside a detailed expression atlas, provide a framework to target candidate genes underpinning agronomic traits in wheat.

KW - Bread

KW - Gene Expression Profiling

KW - Gene Expression Regulation, Developmental

KW - Gene Expression Regulation, Plant

KW - Genome, Plant

KW - Polyploidy

KW - RNA, Plant/genetics

KW - Sequence Analysis, RNA

KW - Transcription, Genetic

KW - Triticum/genetics

U2 - 10.1126/science.aar6089

DO - 10.1126/science.aar6089

M3 - Article

C2 - 30115782

VL - 361

JO - Science

JF - Science

SN - 0036-8075

IS - 6403

M1 - eaar6089

ER -