The thymus medulla fosters generation of natural Treg cells, invariant γδ T Cells and invariant NKT cells : what we learn from intrathymic migration

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@article{339fe6f70b71485f887a8d693ee58901,
title = "The thymus medulla fosters generation of natural Treg cells, invariant γδ T Cells and invariant NKT cells : what we learn from intrathymic migration",
abstract = "The organization of the thymus into distinct cortical and medullary regions enables it to control the step-wise migration and development of immature T-cell precursors. Such a process provides access to specialized cortical and medullary thymic epithelial cells at defined stages of maturation, ensuring the generation of self-tolerant and MHC-restricted conventional CD4+ and CD8+ αβ T cells. The migratory cues and stromal cell requirements that regulate the development of conventional αβ T cells have been well studied. However, the thymus also fosters the generation of several immunoregulatory T-cell populations that form key components of both innate and adaptive immune responses. These include Foxp3+ natural regulatory T cells, invariant γδ T cells, and CD1d-restricted invariant natural killer T cells (iNKT cells). While less is known about the intrathymic requirements of these non-conventional T cells, recent studies have highlighted the importance of the thymus medulla in their development. Here we review recent findings on the mechanisms controlling the intrathymic migration of distinct T-cell subsets, and relate this to knowledge of the microenvironmental requirements of these cells.",
keywords = "Chemokine, iNKT cells, Natural Treg cell, Thymus, Thymic medulla, γδ T cells",
author = "Cowan, {Jennifer E.} and Jenkinson, {William E.} and Graham Anderson",
year = "2015",
month = mar,
doi = "10.1002/eji.201445108",
language = "English",
volume = "45",
pages = "652--660",
journal = "European Journal of Immunology",
issn = "0014-2980",
publisher = "Wiley-VCH Verlag",
number = "3",

}

RIS

TY - JOUR

T1 - The thymus medulla fosters generation of natural Treg cells, invariant γδ T Cells and invariant NKT cells : what we learn from intrathymic migration

AU - Cowan, Jennifer E.

AU - Jenkinson, William E.

AU - Anderson, Graham

PY - 2015/3

Y1 - 2015/3

N2 - The organization of the thymus into distinct cortical and medullary regions enables it to control the step-wise migration and development of immature T-cell precursors. Such a process provides access to specialized cortical and medullary thymic epithelial cells at defined stages of maturation, ensuring the generation of self-tolerant and MHC-restricted conventional CD4+ and CD8+ αβ T cells. The migratory cues and stromal cell requirements that regulate the development of conventional αβ T cells have been well studied. However, the thymus also fosters the generation of several immunoregulatory T-cell populations that form key components of both innate and adaptive immune responses. These include Foxp3+ natural regulatory T cells, invariant γδ T cells, and CD1d-restricted invariant natural killer T cells (iNKT cells). While less is known about the intrathymic requirements of these non-conventional T cells, recent studies have highlighted the importance of the thymus medulla in their development. Here we review recent findings on the mechanisms controlling the intrathymic migration of distinct T-cell subsets, and relate this to knowledge of the microenvironmental requirements of these cells.

AB - The organization of the thymus into distinct cortical and medullary regions enables it to control the step-wise migration and development of immature T-cell precursors. Such a process provides access to specialized cortical and medullary thymic epithelial cells at defined stages of maturation, ensuring the generation of self-tolerant and MHC-restricted conventional CD4+ and CD8+ αβ T cells. The migratory cues and stromal cell requirements that regulate the development of conventional αβ T cells have been well studied. However, the thymus also fosters the generation of several immunoregulatory T-cell populations that form key components of both innate and adaptive immune responses. These include Foxp3+ natural regulatory T cells, invariant γδ T cells, and CD1d-restricted invariant natural killer T cells (iNKT cells). While less is known about the intrathymic requirements of these non-conventional T cells, recent studies have highlighted the importance of the thymus medulla in their development. Here we review recent findings on the mechanisms controlling the intrathymic migration of distinct T-cell subsets, and relate this to knowledge of the microenvironmental requirements of these cells.

KW - Chemokine

KW - iNKT cells

KW - Natural Treg cell

KW - Thymus

KW - Thymic medulla

KW - γδ T cells

U2 - 10.1002/eji.201445108

DO - 10.1002/eji.201445108

M3 - Article

C2 - 25615828

VL - 45

SP - 652

EP - 660

JO - European Journal of Immunology

JF - European Journal of Immunology

SN - 0014-2980

IS - 3

ER -