The thymus and T-cell commitment: the right niche for Notch?

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@article{f98a4734c0614bb2a9b7da51e3f7cab1,
title = "The thymus and T-cell commitment: the right niche for Notch?",
abstract = "The current dogma is that the thymus is colonized by progenitors that retain the capacity to generate both T cells and B cells, and that intrathymic Notch signalling determines lineage choice so that T cells, rather than B cells, develop in the thymus. However, evidence is now accumulating to indicate that, at least during fetal life, this is not the case. Rather, it now seems that the fetal thymus is colonized by progenitors that have already made the T-cell versus B-cell lineage choice. We propose an alternative role for Notch signalling in the thymus, which is not to mediate this choice but instead to reveal it by supporting further T-cell differentiation in the thymic microenvironment.",
author = "Eric Jenkinson and William Jenkinson and Simona Rossi and Graham Anderson",
year = "2006",
month = jul,
day = "1",
doi = "10.1038/nri1883",
language = "English",
volume = "6",
pages = "551--5",
journal = "Nature Reviews Immunology",
issn = "1474-1733",
publisher = "Nature Publishing Group",
number = "7",

}

RIS

TY - JOUR

T1 - The thymus and T-cell commitment: the right niche for Notch?

AU - Jenkinson, Eric

AU - Jenkinson, William

AU - Rossi, Simona

AU - Anderson, Graham

PY - 2006/7/1

Y1 - 2006/7/1

N2 - The current dogma is that the thymus is colonized by progenitors that retain the capacity to generate both T cells and B cells, and that intrathymic Notch signalling determines lineage choice so that T cells, rather than B cells, develop in the thymus. However, evidence is now accumulating to indicate that, at least during fetal life, this is not the case. Rather, it now seems that the fetal thymus is colonized by progenitors that have already made the T-cell versus B-cell lineage choice. We propose an alternative role for Notch signalling in the thymus, which is not to mediate this choice but instead to reveal it by supporting further T-cell differentiation in the thymic microenvironment.

AB - The current dogma is that the thymus is colonized by progenitors that retain the capacity to generate both T cells and B cells, and that intrathymic Notch signalling determines lineage choice so that T cells, rather than B cells, develop in the thymus. However, evidence is now accumulating to indicate that, at least during fetal life, this is not the case. Rather, it now seems that the fetal thymus is colonized by progenitors that have already made the T-cell versus B-cell lineage choice. We propose an alternative role for Notch signalling in the thymus, which is not to mediate this choice but instead to reveal it by supporting further T-cell differentiation in the thymic microenvironment.

UR - http://www.scopus.com/inward/record.url?scp=33745574980&partnerID=8YFLogxK

U2 - 10.1038/nri1883

DO - 10.1038/nri1883

M3 - Article

C2 - 16799474

VL - 6

SP - 551

EP - 555

JO - Nature Reviews Immunology

JF - Nature Reviews Immunology

SN - 1474-1733

IS - 7

ER -