The thick waxy coat of mycobacteria, a protective layer against antibiotics and the host's immune system
Research output: Contribution to journal › Article › peer-review
Colleges, School and Institutes
Tuberculosis, caused by the pathogenic bacterium Mycobacterium tuberculosis (Mtb), is the leading cause of death from an infectious disease, with a mortality rate of over a million people per year. This pathogen's remarkable resilience and infectivity is largely due to its unique waxy cell envelope, 40% of which comprises complex lipids. Therefore, an understanding of the structure and function of the cell wall lipids is of huge indirect clinical significance. This review provides a synopsis of the cell envelope and the major lipids contained within, including structure, biosynthesis and roles in pathogenesis.
|Number of pages||24|
|Journal||The Biochemical journal|
|Publication status||Published - 29 May 2020|
- Cell Membranes, Excitation & Transport, Glycobiology, Microbiology, Molecular Interactions