The T-cell Response to Epstein-Barr Virus-New Tricks From an Old Dog

Research output: Contribution to journalReview articlepeer-review

Colleges, School and Institutes

Abstract

Epstein-Barr virus (EBV) infects most people and establishes life-long infection controlled by the host's immune system. The genetic stability of the virus, deep understanding of the viral antigens and immune epitopes recognized by the host's T-cell system and the fact that recent infection can be identified by the development of symptomatic infectious mononucleosis makes EBV a powerful system in which to study human immunology. The association between EBV and multiple cancers also means that the lessons learned have strong translational potential. Increasing evidence of a role for resident memory T-cells and non-conventional γδ T-cells in controlling EBV infection suggests new opportunities for research and means the virus will continue to provide exciting new insights into human biology and immunology into the future.

Bibliographic note

Copyright © 2019 Long, Meckiff and Taylor.

Details

Original languageEnglish
Article number2193
JournalFrontiers in immunology
Volume10
Publication statusPublished - 18 Sep 2019

Keywords

  • Antigens, Viral/immunology, B-Lymphocytes/immunology, Epstein-Barr Virus Infections/immunology, Herpesvirus 4, Human/immunology, Humans, Immunologic Memory, Receptors, Antigen, T-Cell, gamma-delta/immunology, T-Lymphocytes/immunology

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