The T-cell Response to Epstein-Barr Virus-New Tricks From an Old Dog
Research output: Contribution to journal › Review article › peer-review
Colleges, School and Institutes
Epstein-Barr virus (EBV) infects most people and establishes life-long infection controlled by the host's immune system. The genetic stability of the virus, deep understanding of the viral antigens and immune epitopes recognized by the host's T-cell system and the fact that recent infection can be identified by the development of symptomatic infectious mononucleosis makes EBV a powerful system in which to study human immunology. The association between EBV and multiple cancers also means that the lessons learned have strong translational potential. Increasing evidence of a role for resident memory T-cells and non-conventional γδ T-cells in controlling EBV infection suggests new opportunities for research and means the virus will continue to provide exciting new insights into human biology and immunology into the future.
|Journal||Frontiers in immunology|
|Publication status||Published - 18 Sep 2019|
- Antigens, Viral/immunology, B-Lymphocytes/immunology, Epstein-Barr Virus Infections/immunology, Herpesvirus 4, Human/immunology, Humans, Immunologic Memory, Receptors, Antigen, T-Cell, gamma-delta/immunology, T-Lymphocytes/immunology