Projects per year
Abstract
Female androgen excess and male androgen deficiency manifest with an overlapping adverse metabolic phenotype, including abdominal obesity, insulin resistance, type 2 diabetes mellitus, non alcoholic fatty liver disease and an increased risk of cardiovascular disease. Here we review the impact of androgens on metabolic target tissues in an attempt to unravel the complex mechanistic
links with metabolic dysfunction; we also evaluate clinical studies examining the associations between metabolic disease and disorders of androgen metabolism in men and women. We conceptualise that an equilibrium between androgen effects on adipose tissue and skeletal muscle underpins the metabolic phenotype observed in female androgen excess and male androgen deficiency. Androgens induce adipose tissue dysfunction, with effects on lipid metabolism, insulin resistance and fat mass expansion, while anabolic effects on skeletal muscle may confer metabolic benefits. We hypothesise that serum androgen concentrations observed in female androgen excess and male hypogonadism are metabolically disadvantageous, promoting adipose and liver lipid accumulation, central fat mass expansion and insulin resistance.
links with metabolic dysfunction; we also evaluate clinical studies examining the associations between metabolic disease and disorders of androgen metabolism in men and women. We conceptualise that an equilibrium between androgen effects on adipose tissue and skeletal muscle underpins the metabolic phenotype observed in female androgen excess and male androgen deficiency. Androgens induce adipose tissue dysfunction, with effects on lipid metabolism, insulin resistance and fat mass expansion, while anabolic effects on skeletal muscle may confer metabolic benefits. We hypothesise that serum androgen concentrations observed in female androgen excess and male hypogonadism are metabolically disadvantageous, promoting adipose and liver lipid accumulation, central fat mass expansion and insulin resistance.
Original language | English |
---|---|
Pages (from-to) | R125-R143 |
Journal | European Journal of Endocrinology |
Volume | 177 |
Early online date | 31 May 2017 |
DOIs | |
Publication status | Published - 1 Sept 2017 |
Keywords
- androgen
- metabolic disease
- male hypogonadism
- polycystic ovary syndrome
Fingerprint
Dive into the research topics of 'The sexually dimorphic role of androgens in human metabolic disease'. Together they form a unique fingerprint.Projects
- 1 Finished
-
Unravelling the Link Between Insulin Resistance and Androgen Excess (M. O'Reilly)
1/08/12 → 31/07/15
Project: Research