The RUNX1-PU.1 axis in the control of hematopoiesis

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@article{8c630ffcd0084d6ba629f798af0259f7,
title = "The RUNX1-PU.1 axis in the control of hematopoiesis",
abstract = "The differentiation from multipotent hematopoietic stem cells (HSC) to mature and functional blood cells requires the finely tuned regulation of gene expression at each stage of development. Specific transcription factors play a key role in this process as they modulate the expression of their target genes in an exquisitely lineage-specific manner. A large number of important transcriptional regulators have been identified which establish and maintain specific gene expression patterns during hematopoietic development. Hematopoiesis is therefore a paradigm for investigating how transcription factors function in mammalian cells, thanks also to the evolution of genome-wide and the next-generation sequencing technologies. In this review, we focus on the current knowledge of the biological and functional properties of the hematopoietic master regulator RUNX1 (also known as AML1, CBFA2, PEBP2aB) transcription factor and its main downstream target PU.1. We will outline their relationship in determining the fate of the myeloid lineage during normal stem cell development and under conditions when hematopoietic development is subverted by leukemic transformation.",
keywords = "hematopoiesis, RUNX1, PU.1, Transcriptional regulation, Epigenetics, Acute myeloid leukemia",
author = "Imperato, {Maria Rosaria} and Pierre Cauchy and Nadine Obier and Constanze Bonifer",
year = "2015",
month = apr,
doi = "10.1007/s12185-015-1762-8",
language = "English",
volume = "101",
pages = "319--329",
journal = "International journal of hematology",
issn = "0925-5710",
publisher = "Springer",
number = "4",

}

RIS

TY - JOUR

T1 - The RUNX1-PU.1 axis in the control of hematopoiesis

AU - Imperato, Maria Rosaria

AU - Cauchy, Pierre

AU - Obier, Nadine

AU - Bonifer, Constanze

PY - 2015/4

Y1 - 2015/4

N2 - The differentiation from multipotent hematopoietic stem cells (HSC) to mature and functional blood cells requires the finely tuned regulation of gene expression at each stage of development. Specific transcription factors play a key role in this process as they modulate the expression of their target genes in an exquisitely lineage-specific manner. A large number of important transcriptional regulators have been identified which establish and maintain specific gene expression patterns during hematopoietic development. Hematopoiesis is therefore a paradigm for investigating how transcription factors function in mammalian cells, thanks also to the evolution of genome-wide and the next-generation sequencing technologies. In this review, we focus on the current knowledge of the biological and functional properties of the hematopoietic master regulator RUNX1 (also known as AML1, CBFA2, PEBP2aB) transcription factor and its main downstream target PU.1. We will outline their relationship in determining the fate of the myeloid lineage during normal stem cell development and under conditions when hematopoietic development is subverted by leukemic transformation.

AB - The differentiation from multipotent hematopoietic stem cells (HSC) to mature and functional blood cells requires the finely tuned regulation of gene expression at each stage of development. Specific transcription factors play a key role in this process as they modulate the expression of their target genes in an exquisitely lineage-specific manner. A large number of important transcriptional regulators have been identified which establish and maintain specific gene expression patterns during hematopoietic development. Hematopoiesis is therefore a paradigm for investigating how transcription factors function in mammalian cells, thanks also to the evolution of genome-wide and the next-generation sequencing technologies. In this review, we focus on the current knowledge of the biological and functional properties of the hematopoietic master regulator RUNX1 (also known as AML1, CBFA2, PEBP2aB) transcription factor and its main downstream target PU.1. We will outline their relationship in determining the fate of the myeloid lineage during normal stem cell development and under conditions when hematopoietic development is subverted by leukemic transformation.

KW - hematopoiesis

KW - RUNX1

KW - PU.1

KW - Transcriptional regulation

KW - Epigenetics

KW - Acute myeloid leukemia

U2 - 10.1007/s12185-015-1762-8

DO - 10.1007/s12185-015-1762-8

M3 - Article

C2 - 25749719

VL - 101

SP - 319

EP - 329

JO - International journal of hematology

JF - International journal of hematology

SN - 0925-5710

IS - 4

ER -