The role of the natural environment in the emergence of antibiotic resistance in gram-negative bacteria

Research output: Contribution to journalArticlepeer-review

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The role of the natural environment in the emergence of antibiotic resistance in gram-negative bacteria. / Wellington, Elizabeth M H; Boxall, Alistair B; Cross, Paul; Feil, Edward J; Gaze, William H; Hawkey, Peter M; Johnson-Rollings, Ashley S; Jones, Davey L; Lee, Nicholas M; Otten, Wilfred; Williams, A Prysor; Thomas, Christopher.

In: The Lancet Infectious Diseases, Vol. 13, No. 2, 02.2013, p. 155-65.

Research output: Contribution to journalArticlepeer-review

Harvard

Wellington, EMH, Boxall, AB, Cross, P, Feil, EJ, Gaze, WH, Hawkey, PM, Johnson-Rollings, AS, Jones, DL, Lee, NM, Otten, W, Williams, AP & Thomas, C 2013, 'The role of the natural environment in the emergence of antibiotic resistance in gram-negative bacteria', The Lancet Infectious Diseases, vol. 13, no. 2, pp. 155-65. https://doi.org/10.1016/S1473-3099(12)70317-1

APA

Wellington, E. M. H., Boxall, A. B., Cross, P., Feil, E. J., Gaze, W. H., Hawkey, P. M., Johnson-Rollings, A. S., Jones, D. L., Lee, N. M., Otten, W., Williams, A. P., & Thomas, C. (2013). The role of the natural environment in the emergence of antibiotic resistance in gram-negative bacteria. The Lancet Infectious Diseases, 13(2), 155-65. https://doi.org/10.1016/S1473-3099(12)70317-1

Vancouver

Author

Wellington, Elizabeth M H ; Boxall, Alistair B ; Cross, Paul ; Feil, Edward J ; Gaze, William H ; Hawkey, Peter M ; Johnson-Rollings, Ashley S ; Jones, Davey L ; Lee, Nicholas M ; Otten, Wilfred ; Williams, A Prysor ; Thomas, Christopher. / The role of the natural environment in the emergence of antibiotic resistance in gram-negative bacteria. In: The Lancet Infectious Diseases. 2013 ; Vol. 13, No. 2. pp. 155-65.

Bibtex

@article{d8aca5aee9ab4e4287eb78b0023739e4,
title = "The role of the natural environment in the emergence of antibiotic resistance in gram-negative bacteria",
abstract = "During the past 10 years, multidrug-resistant Gram-negative Enterobacteriaceae have become a substantial challenge to infection control. It has been suggested by clinicians that the effectiveness of antibiotics is in such rapid decline that, depending on the pathogen concerned, their future utility can be measured in decades or even years. Unless the rise in antibiotic resistance can be reversed, we can expect to see a substantial rise in incurable infection and fatality in both developed and developing regions. Antibiotic resistance develops through complex interactions, with resistance arising by de-novo mutation under clinical antibiotic selection or frequently by acquisition of mobile genes that have evolved over time in bacteria in the environment. The reservoir of resistance genes in the environment is due to a mix of naturally occurring resistance and those present in animal and human waste and the selective effects of pollutants, which can co-select for mobile genetic elements carrying multiple resistant genes. Less attention has been given to how anthropogenic activity might be causing evolution of antibiotic resistance in the environment. Although the economics of the pharmaceutical industry continue to restrict investment in novel biomedical responses, action must be taken to avoid the conjunction of factors that promote evolution and spread of antibiotic resistance.",
author = "Wellington, {Elizabeth M H} and Boxall, {Alistair B} and Paul Cross and Feil, {Edward J} and Gaze, {William H} and Hawkey, {Peter M} and Johnson-Rollings, {Ashley S} and Jones, {Davey L} and Lee, {Nicholas M} and Wilfred Otten and Williams, {A Prysor} and Christopher Thomas",
year = "2013",
month = feb,
doi = "10.1016/S1473-3099(12)70317-1",
language = "English",
volume = "13",
pages = "155--65",
journal = "The Lancet Infectious Diseases",
issn = "1473-3099",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - The role of the natural environment in the emergence of antibiotic resistance in gram-negative bacteria

AU - Wellington, Elizabeth M H

AU - Boxall, Alistair B

AU - Cross, Paul

AU - Feil, Edward J

AU - Gaze, William H

AU - Hawkey, Peter M

AU - Johnson-Rollings, Ashley S

AU - Jones, Davey L

AU - Lee, Nicholas M

AU - Otten, Wilfred

AU - Williams, A Prysor

AU - Thomas, Christopher

PY - 2013/2

Y1 - 2013/2

N2 - During the past 10 years, multidrug-resistant Gram-negative Enterobacteriaceae have become a substantial challenge to infection control. It has been suggested by clinicians that the effectiveness of antibiotics is in such rapid decline that, depending on the pathogen concerned, their future utility can be measured in decades or even years. Unless the rise in antibiotic resistance can be reversed, we can expect to see a substantial rise in incurable infection and fatality in both developed and developing regions. Antibiotic resistance develops through complex interactions, with resistance arising by de-novo mutation under clinical antibiotic selection or frequently by acquisition of mobile genes that have evolved over time in bacteria in the environment. The reservoir of resistance genes in the environment is due to a mix of naturally occurring resistance and those present in animal and human waste and the selective effects of pollutants, which can co-select for mobile genetic elements carrying multiple resistant genes. Less attention has been given to how anthropogenic activity might be causing evolution of antibiotic resistance in the environment. Although the economics of the pharmaceutical industry continue to restrict investment in novel biomedical responses, action must be taken to avoid the conjunction of factors that promote evolution and spread of antibiotic resistance.

AB - During the past 10 years, multidrug-resistant Gram-negative Enterobacteriaceae have become a substantial challenge to infection control. It has been suggested by clinicians that the effectiveness of antibiotics is in such rapid decline that, depending on the pathogen concerned, their future utility can be measured in decades or even years. Unless the rise in antibiotic resistance can be reversed, we can expect to see a substantial rise in incurable infection and fatality in both developed and developing regions. Antibiotic resistance develops through complex interactions, with resistance arising by de-novo mutation under clinical antibiotic selection or frequently by acquisition of mobile genes that have evolved over time in bacteria in the environment. The reservoir of resistance genes in the environment is due to a mix of naturally occurring resistance and those present in animal and human waste and the selective effects of pollutants, which can co-select for mobile genetic elements carrying multiple resistant genes. Less attention has been given to how anthropogenic activity might be causing evolution of antibiotic resistance in the environment. Although the economics of the pharmaceutical industry continue to restrict investment in novel biomedical responses, action must be taken to avoid the conjunction of factors that promote evolution and spread of antibiotic resistance.

U2 - 10.1016/S1473-3099(12)70317-1

DO - 10.1016/S1473-3099(12)70317-1

M3 - Article

C2 - 23347633

VL - 13

SP - 155

EP - 165

JO - The Lancet Infectious Diseases

JF - The Lancet Infectious Diseases

SN - 1473-3099

IS - 2

ER -