The role of Syk/CARD9 coupled C-type lectins in antifungal immunity

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The role of Syk/CARD9 coupled C-type lectins in antifungal immunity. / Drummond, Rebecca A.; Saijo, Shinobu; Iwakura, Yoichiro; Brown, Gordon D.

In: European Journal of Immunology, Vol. 41, No. 2, 02.2011, p. 276-281.

Research output: Contribution to journalReview articlepeer-review

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Drummond, Rebecca A. ; Saijo, Shinobu ; Iwakura, Yoichiro ; Brown, Gordon D. / The role of Syk/CARD9 coupled C-type lectins in antifungal immunity. In: European Journal of Immunology. 2011 ; Vol. 41, No. 2. pp. 276-281.

Bibtex

@article{66b317544d6a42008026f8f2d5d0a615,
title = "The role of Syk/CARD9 coupled C-type lectins in antifungal immunity",
abstract = "Fungal infections are affecting an increasing number of people, and the failure of current therapies in treating systemic infection has resulted in an unacceptably high mortality rate. It is therefore of importance that we understand immune mechanisms operating during fungal infections, in order to facilitate development of adjunctive immunotherapies for the treatment of these diseases. C-type lectin receptors (CLRs) are pattern recognition receptors (PRRs) that are critical for immune responses to fungi. Many of these receptors are coupled to Syk kinase, which allows these receptors to signal via CARD9 leading to NF-κB activation, which in turn contributes to the induction of both innate and adaptive immunity. Dectin-1, Dectin-2 and Mincle are all CLRs that share this common signalling mechanism and have been shown to play key roles in antifungal immunity. This review aims to update existing paradigms and summarise the most recent findings on these CLRs, their signal transduction mechanisms and the collaborations between these CLRs and other PRRs.",
keywords = "Antifungal immunity, Dectin-1, Dectin-2, Mincle",
author = "Drummond, {Rebecca A.} and Shinobu Saijo and Yoichiro Iwakura and Brown, {Gordon D.}",
year = "2011",
month = feb,
doi = "10.1002/eji.201041252",
language = "English",
volume = "41",
pages = "276--281",
journal = "European Journal of Immunology",
issn = "0014-2980",
publisher = "Wiley-VCH Verlag",
number = "2",

}

RIS

TY - JOUR

T1 - The role of Syk/CARD9 coupled C-type lectins in antifungal immunity

AU - Drummond, Rebecca A.

AU - Saijo, Shinobu

AU - Iwakura, Yoichiro

AU - Brown, Gordon D.

PY - 2011/2

Y1 - 2011/2

N2 - Fungal infections are affecting an increasing number of people, and the failure of current therapies in treating systemic infection has resulted in an unacceptably high mortality rate. It is therefore of importance that we understand immune mechanisms operating during fungal infections, in order to facilitate development of adjunctive immunotherapies for the treatment of these diseases. C-type lectin receptors (CLRs) are pattern recognition receptors (PRRs) that are critical for immune responses to fungi. Many of these receptors are coupled to Syk kinase, which allows these receptors to signal via CARD9 leading to NF-κB activation, which in turn contributes to the induction of both innate and adaptive immunity. Dectin-1, Dectin-2 and Mincle are all CLRs that share this common signalling mechanism and have been shown to play key roles in antifungal immunity. This review aims to update existing paradigms and summarise the most recent findings on these CLRs, their signal transduction mechanisms and the collaborations between these CLRs and other PRRs.

AB - Fungal infections are affecting an increasing number of people, and the failure of current therapies in treating systemic infection has resulted in an unacceptably high mortality rate. It is therefore of importance that we understand immune mechanisms operating during fungal infections, in order to facilitate development of adjunctive immunotherapies for the treatment of these diseases. C-type lectin receptors (CLRs) are pattern recognition receptors (PRRs) that are critical for immune responses to fungi. Many of these receptors are coupled to Syk kinase, which allows these receptors to signal via CARD9 leading to NF-κB activation, which in turn contributes to the induction of both innate and adaptive immunity. Dectin-1, Dectin-2 and Mincle are all CLRs that share this common signalling mechanism and have been shown to play key roles in antifungal immunity. This review aims to update existing paradigms and summarise the most recent findings on these CLRs, their signal transduction mechanisms and the collaborations between these CLRs and other PRRs.

KW - Antifungal immunity

KW - Dectin-1

KW - Dectin-2

KW - Mincle

UR - http://www.scopus.com/inward/record.url?scp=78851471443&partnerID=8YFLogxK

U2 - 10.1002/eji.201041252

DO - 10.1002/eji.201041252

M3 - Review article

C2 - 21267996

AN - SCOPUS:78851471443

VL - 41

SP - 276

EP - 281

JO - European Journal of Immunology

JF - European Journal of Immunology

SN - 0014-2980

IS - 2

ER -