The role of self-reported stress in the development of breast cancer and prostate cancer: A prospective cohort study of employed males and females with 30 years of follow-up

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@article{9aaf650a8aed4cfdb149a2f446b19876,
title = "The role of self-reported stress in the development of breast cancer and prostate cancer: A prospective cohort study of employed males and females with 30 years of follow-up",
abstract = "We investigate the association between psychological stress and breast cancer and, as oestrogen may provide a common mechanism, the association between stress and prostate cancer. A prospective study of 991 women and 5743 men employed in Scotland in the 1970s provided data. Risk exposure was measured by questionnaire and physical examination, routine data collection provided cancer outcomes over the subsequent 30 years. There was weak evidence of elevated incidences in those reporting moderate (breast cancer: hazard ratio [HR] 2.16, 95% CI 1.00-4.71; prostate cancer: HR 1.65, 95% Cl 1.20-2.27) and high stress (breast cancer: HR 1.92, 95% CI 0.81-4.55; prostate cancer: HR 1.35, 95% CI 0.872.10) compared to those reporting low stress. These estimates are adjusted for socioeconomic circumstances and health-related behaviours. With no dose-response relationship and no established mechanism linking stress with breast and prostate cancer, confounding is the parsimonious explanation of these findings. (C) 2007 Elsevier Ltd. All rights reserved.",
keywords = "Scotland, socioeconomic factors, prospective studies, mortality, stress, psychological, prostatic neoplasms, breast neoplasms",
author = "C Metcalfe and GD Smith and John Macleod and C Hart",
year = "2007",
month = apr,
day = "1",
doi = "10.1016/j.ejca.2007.01.027",
language = "English",
volume = "43",
pages = "1060--1065",
journal = "European Journal of Cancer",
issn = "0959-8049",
publisher = "Elsevier",
number = "6",

}

RIS

TY - JOUR

T1 - The role of self-reported stress in the development of breast cancer and prostate cancer: A prospective cohort study of employed males and females with 30 years of follow-up

AU - Metcalfe, C

AU - Smith, GD

AU - Macleod, John

AU - Hart, C

PY - 2007/4/1

Y1 - 2007/4/1

N2 - We investigate the association between psychological stress and breast cancer and, as oestrogen may provide a common mechanism, the association between stress and prostate cancer. A prospective study of 991 women and 5743 men employed in Scotland in the 1970s provided data. Risk exposure was measured by questionnaire and physical examination, routine data collection provided cancer outcomes over the subsequent 30 years. There was weak evidence of elevated incidences in those reporting moderate (breast cancer: hazard ratio [HR] 2.16, 95% CI 1.00-4.71; prostate cancer: HR 1.65, 95% Cl 1.20-2.27) and high stress (breast cancer: HR 1.92, 95% CI 0.81-4.55; prostate cancer: HR 1.35, 95% CI 0.872.10) compared to those reporting low stress. These estimates are adjusted for socioeconomic circumstances and health-related behaviours. With no dose-response relationship and no established mechanism linking stress with breast and prostate cancer, confounding is the parsimonious explanation of these findings. (C) 2007 Elsevier Ltd. All rights reserved.

AB - We investigate the association between psychological stress and breast cancer and, as oestrogen may provide a common mechanism, the association between stress and prostate cancer. A prospective study of 991 women and 5743 men employed in Scotland in the 1970s provided data. Risk exposure was measured by questionnaire and physical examination, routine data collection provided cancer outcomes over the subsequent 30 years. There was weak evidence of elevated incidences in those reporting moderate (breast cancer: hazard ratio [HR] 2.16, 95% CI 1.00-4.71; prostate cancer: HR 1.65, 95% Cl 1.20-2.27) and high stress (breast cancer: HR 1.92, 95% CI 0.81-4.55; prostate cancer: HR 1.35, 95% CI 0.872.10) compared to those reporting low stress. These estimates are adjusted for socioeconomic circumstances and health-related behaviours. With no dose-response relationship and no established mechanism linking stress with breast and prostate cancer, confounding is the parsimonious explanation of these findings. (C) 2007 Elsevier Ltd. All rights reserved.

KW - Scotland

KW - socioeconomic factors

KW - prospective studies

KW - mortality

KW - stress, psychological

KW - prostatic neoplasms

KW - breast neoplasms

U2 - 10.1016/j.ejca.2007.01.027

DO - 10.1016/j.ejca.2007.01.027

M3 - Article

C2 - 17336053

VL - 43

SP - 1060

EP - 1065

JO - European Journal of Cancer

JF - European Journal of Cancer

SN - 0959-8049

IS - 6

ER -