Abstract
Inflammation results from the complex interaction between hematopoietic and stromal cells and growing evidence supports a key role for the stroma in driving the switch from acute resolving to persistence in chronic inflammatory diseases. Stromal cells have also been shown to play a critical role in cancer biology, being involved in cancer growth, dissemination, and inhibition of the autologous immune response, ultimately favoring persistence and metastatic spread. Similarly, blood and lymphatic endothelial cells contribute to tissue homeostasis during physiological inflammation but also lead to discorded leukocyte and tumor cell accumulation in pathological inflammation and cancer. This review aims to summarize the role that pathogenic stroma plays in the pathogenesis of diseases such as cancer and chronic inflammation.
| Original language | English |
|---|---|
| Journal | Frontiers in immunology |
| Volume | 3 |
| Issue number | 416 |
| Early online date | 14 Jan 2013 |
| DOIs | |
| Publication status | E-pub ahead of print - 14 Jan 2013 |
Keywords
- endothelium
- lymphatics
- rheumatoid arthritis
- ectopic lymphoneogenesis
- fibroblasts
Access to Document
- Barone_et_al_The_Role_of_non_hematopoietic_frontiers_in_immunology_2013
Checked for eligibility: 08/12/2015. Copyright: © 2013 Barone, Nayar and Buckley. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc