The Role of Myeloid-Derived Cells in the Progression of Liver Disease

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The Role of Myeloid-Derived Cells in the Progression of Liver Disease. / Weston, Chris John; Zimmermann, Henning Wolfgang; Adams, David H.

In: Frontiers in immunology, Vol. 10, 893, 24.04.2019.

Research output: Contribution to journalReview articlepeer-review

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@article{0d5907ba9dc04db0a8c1598979a5ecf2,
title = "The Role of Myeloid-Derived Cells in the Progression of Liver Disease",
abstract = "Control of homeostasis and rapid response to tissue damage in the liver is orchestrated by crosstalk between resident and infiltrating inflammatory cells. A crucial role for myeloid cells during hepatic injury and repair has emerged where resident Kupffer cells, circulating monocytes, macrophages, dendritic cells and neutrophils control local tissue inflammation and regenerative function to maintain tissue architecture. Studies in humans and rodents have revealed a heterogeneous population of myeloid cells that respond to the local environment by either promoting regeneration or driving the inflammatory processes that can lead to hepatitis, fibrogenesis, and the development of cirrhosis and malignancy. Such plasticity of myeloid cell responses presents unique challenges for therapeutic intervention strategies and a greater understanding of the underlying mechanisms is needed. Here we review the role of myeloid cells in the establishment and progression of liver disease and highlight key pathways that have become the focus for current and future therapeutic strategies.",
keywords = "circulating monocytes, cirrhosis, fibrosis, hepatitis (general), hepatocellular carcinoma, macrophage, myeloid derived suppressor cell (MDSC), neutrophil (PMN)",
author = "Weston, {Chris John} and Zimmermann, {Henning Wolfgang} and Adams, {David H}",
year = "2019",
month = apr,
day = "24",
doi = "10.3389/fimmu.2019.00893",
language = "English",
volume = "10",
journal = "Frontiers in immunology",
issn = "1664-3224",
publisher = "Frontiers",

}

RIS

TY - JOUR

T1 - The Role of Myeloid-Derived Cells in the Progression of Liver Disease

AU - Weston, Chris John

AU - Zimmermann, Henning Wolfgang

AU - Adams, David H

PY - 2019/4/24

Y1 - 2019/4/24

N2 - Control of homeostasis and rapid response to tissue damage in the liver is orchestrated by crosstalk between resident and infiltrating inflammatory cells. A crucial role for myeloid cells during hepatic injury and repair has emerged where resident Kupffer cells, circulating monocytes, macrophages, dendritic cells and neutrophils control local tissue inflammation and regenerative function to maintain tissue architecture. Studies in humans and rodents have revealed a heterogeneous population of myeloid cells that respond to the local environment by either promoting regeneration or driving the inflammatory processes that can lead to hepatitis, fibrogenesis, and the development of cirrhosis and malignancy. Such plasticity of myeloid cell responses presents unique challenges for therapeutic intervention strategies and a greater understanding of the underlying mechanisms is needed. Here we review the role of myeloid cells in the establishment and progression of liver disease and highlight key pathways that have become the focus for current and future therapeutic strategies.

AB - Control of homeostasis and rapid response to tissue damage in the liver is orchestrated by crosstalk between resident and infiltrating inflammatory cells. A crucial role for myeloid cells during hepatic injury and repair has emerged where resident Kupffer cells, circulating monocytes, macrophages, dendritic cells and neutrophils control local tissue inflammation and regenerative function to maintain tissue architecture. Studies in humans and rodents have revealed a heterogeneous population of myeloid cells that respond to the local environment by either promoting regeneration or driving the inflammatory processes that can lead to hepatitis, fibrogenesis, and the development of cirrhosis and malignancy. Such plasticity of myeloid cell responses presents unique challenges for therapeutic intervention strategies and a greater understanding of the underlying mechanisms is needed. Here we review the role of myeloid cells in the establishment and progression of liver disease and highlight key pathways that have become the focus for current and future therapeutic strategies.

KW - circulating monocytes

KW - cirrhosis

KW - fibrosis

KW - hepatitis (general)

KW - hepatocellular carcinoma

KW - macrophage

KW - myeloid derived suppressor cell (MDSC)

KW - neutrophil (PMN)

U2 - 10.3389/fimmu.2019.00893

DO - 10.3389/fimmu.2019.00893

M3 - Review article

C2 - 31068952

VL - 10

JO - Frontiers in immunology

JF - Frontiers in immunology

SN - 1664-3224

M1 - 893

ER -