The role of metabolic reprogramming in γ-herpesvirus-associated oncogenesis

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The role of metabolic reprogramming in γ-herpesvirus-associated oncogenesis. / Lo, Angela Kwok-Fung; Dawson, Christopher W.; Young, Lawrence S.; Lo, Kwok-Wai.

In: International Journal of Cancer, Vol. 141, No. 8, 15.10.2017, p. 1512-1521.

Research output: Contribution to journalReview article

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Lo, Angela Kwok-Fung ; Dawson, Christopher W. ; Young, Lawrence S. ; Lo, Kwok-Wai. / The role of metabolic reprogramming in γ-herpesvirus-associated oncogenesis. In: International Journal of Cancer. 2017 ; Vol. 141, No. 8. pp. 1512-1521.

Bibtex

@article{03d2d70eed5e4da586aaac8d94b28b49,
title = "The role of metabolic reprogramming in γ-herpesvirus-associated oncogenesis",
abstract = "The γ-herpesviruses, EBV and KSHV, are closely associated with a number of human cancers. While the signal transduction pathways exploited by γ-herpesviruses to promote cell growth, survival and transformation have been reported, recent studies have uncovered the impact of γ-herpesvirus infection on host cell metabolism. Here, we review the mechanisms used by γ-herpesviruses to induce metabolic reprogramming in host cells, focusing on their ability to modulate the activity of metabolic regulators and manipulate metabolic pathways. While γ-herpesviruses alter metabolic phenotypes as a means to support viral infection and long-term persistence, this modulation can inadvertently contribute to cancer development. Strategies that target deregulated metabolic phenotypes induced by γ-herpesviruses provide new opportunities for therapeutic intervention.",
keywords = "Carcinogenesis, Cellular Reprogramming, Epstein-Barr Virus Infections, Herpesviridae Infections, Herpesvirus 4, Human, Herpesvirus 8, Human, Humans, Neoplasms, Journal Article, Review, metabolism , transformation",
author = "Lo, {Angela Kwok-Fung} and Dawson, {Christopher W.} and Young, {Lawrence S.} and Kwok-Wai Lo",
note = "{\textcopyright} 2017 UICC.",
year = "2017",
month = oct
day = "15",
doi = "10.1002/ijc.30795",
language = "English",
volume = "141",
pages = "1512--1521",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "Wiley",
number = "8",

}

RIS

TY - JOUR

T1 - The role of metabolic reprogramming in γ-herpesvirus-associated oncogenesis

AU - Lo, Angela Kwok-Fung

AU - Dawson, Christopher W.

AU - Young, Lawrence S.

AU - Lo, Kwok-Wai

N1 - © 2017 UICC.

PY - 2017/10/15

Y1 - 2017/10/15

N2 - The γ-herpesviruses, EBV and KSHV, are closely associated with a number of human cancers. While the signal transduction pathways exploited by γ-herpesviruses to promote cell growth, survival and transformation have been reported, recent studies have uncovered the impact of γ-herpesvirus infection on host cell metabolism. Here, we review the mechanisms used by γ-herpesviruses to induce metabolic reprogramming in host cells, focusing on their ability to modulate the activity of metabolic regulators and manipulate metabolic pathways. While γ-herpesviruses alter metabolic phenotypes as a means to support viral infection and long-term persistence, this modulation can inadvertently contribute to cancer development. Strategies that target deregulated metabolic phenotypes induced by γ-herpesviruses provide new opportunities for therapeutic intervention.

AB - The γ-herpesviruses, EBV and KSHV, are closely associated with a number of human cancers. While the signal transduction pathways exploited by γ-herpesviruses to promote cell growth, survival and transformation have been reported, recent studies have uncovered the impact of γ-herpesvirus infection on host cell metabolism. Here, we review the mechanisms used by γ-herpesviruses to induce metabolic reprogramming in host cells, focusing on their ability to modulate the activity of metabolic regulators and manipulate metabolic pathways. While γ-herpesviruses alter metabolic phenotypes as a means to support viral infection and long-term persistence, this modulation can inadvertently contribute to cancer development. Strategies that target deregulated metabolic phenotypes induced by γ-herpesviruses provide new opportunities for therapeutic intervention.

KW - Carcinogenesis

KW - Cellular Reprogramming

KW - Epstein-Barr Virus Infections

KW - Herpesviridae Infections

KW - Herpesvirus 4, Human

KW - Herpesvirus 8, Human

KW - Humans

KW - Neoplasms

KW - Journal Article

KW - Review

KW - metabolism

KW - transformation

U2 - 10.1002/ijc.30795

DO - 10.1002/ijc.30795

M3 - Review article

C2 - 28542909

VL - 141

SP - 1512

EP - 1521

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 8

ER -