The role of metabolic reprogramming in γ-herpesvirus-associated oncogenesis

Research output: Contribution to journalReview article

Authors

Colleges, School and Institutes

External organisations

  • Department of Anatomical and Cellular Pathology, State Key Laboratory in Oncology in South China and Li Ka Shing Institute of Health Science, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.
  • Warwick Medical School, University of Warwick

Abstract

The γ-herpesviruses, EBV and KSHV, are closely associated with a number of human cancers. While the signal transduction pathways exploited by γ-herpesviruses to promote cell growth, survival and transformation have been reported, recent studies have uncovered the impact of γ-herpesvirus infection on host cell metabolism. Here, we review the mechanisms used by γ-herpesviruses to induce metabolic reprogramming in host cells, focusing on their ability to modulate the activity of metabolic regulators and manipulate metabolic pathways. While γ-herpesviruses alter metabolic phenotypes as a means to support viral infection and long-term persistence, this modulation can inadvertently contribute to cancer development. Strategies that target deregulated metabolic phenotypes induced by γ-herpesviruses provide new opportunities for therapeutic intervention.

Details

Original languageEnglish
Pages (from-to)1512-1521
Number of pages10
JournalInternational Journal of Cancer
Volume141
Issue number8
Early online date7 Jun 2017
Publication statusPublished - 15 Oct 2017

Keywords

  • Carcinogenesis, Cellular Reprogramming, Epstein-Barr Virus Infections, Herpesviridae Infections, Herpesvirus 4, Human, Herpesvirus 8, Human, Humans, Neoplasms, Journal Article, Review, metabolism , transformation