Abstract
The γ-herpesviruses, EBV and KSHV, are closely associated with a number of human cancers. While the signal transduction pathways exploited by γ-herpesviruses to promote cell growth, survival and transformation have been reported, recent studies have uncovered the impact of γ-herpesvirus infection on host cell metabolism. Here, we review the mechanisms used by γ-herpesviruses to induce metabolic reprogramming in host cells, focusing on their ability to modulate the activity of metabolic regulators and manipulate metabolic pathways. While γ-herpesviruses alter metabolic phenotypes as a means to support viral infection and long-term persistence, this modulation can inadvertently contribute to cancer development. Strategies that target deregulated metabolic phenotypes induced by γ-herpesviruses provide new opportunities for therapeutic intervention.
| Original language | English |
|---|---|
| Pages (from-to) | 1512-1521 |
| Number of pages | 10 |
| Journal | International Journal of Cancer |
| Volume | 141 |
| Issue number | 8 |
| Early online date | 7 Jun 2017 |
| DOIs | |
| Publication status | Published - 15 Oct 2017 |
Keywords
- Carcinogenesis
- Cellular Reprogramming
- Epstein-Barr Virus Infections
- Herpesviridae Infections
- Herpesvirus 4, Human
- Herpesvirus 8, Human
- Humans
- Neoplasms
- Journal Article
- Review
- metabolism
- transformation
Access to Document
- Lo_et_al_The_role_of_metabolic_reprogramming_IJC_2017
This is the peer reviewed version of the following article: Lo, A. K.-F., Dawson, C. W., Young, L. S. and Lo, K.-W. (2017), The role of metabolic reprogramming in γ-herpesvirus-associated oncogenesis. Int. J. Cancer, 141: 1512–1521. doi:10.1002/ijc.30795, which has been published in final form at 10.1002/ijc.30795 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.