The role of leukocyte-stromal interactions in chronic inflammatory joint disease

Angela Burman; Oliver Haworth; Paul Bradfield; Gregory Parsonage; Andrew Filer; Andrew M C Thomas; Esther Amft; Michael Salmon; Christopher D Buckley

doi:10.1016/j.jbspin.2004.03.009

The role of leukocyte-stromal interactions in chronic inflammatory joint disease

Angela Burman, Oliver Haworth, Paul Bradfield, Gregory Parsonage, Andrew Filer, Andrew M C Thomas, Esther Amft, Michael Salmon, Christopher D Buckley

Immunology and Immunotherapy

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Abstract

Rheumatoid arthritis (RA) is a debilitating, chronic, persistent inflammatory disease that is characterised by painful and swollen joints. The aetiology of RA is unknown, however whereas past research has concentrated on the role of immune or inflammatory infiltrating cells in inflammation, it is becoming clear that stromal cells play a critical part in regulating the quality and duration of an inflammatory response. In this review we assess the role of fibroblasts within the inflamed synovium in modulating immune responses; in particular we examine the role of stromal cells in the switch from resolving to persistent inflammation as is found in the rheumatoid synovium.

Original language	English
Pages (from-to)	10-16
Number of pages	7
Journal	Joint Bone Spine
Volume	72
Issue number	1
Early online date	8 Jun 2004
DOIs	https://doi.org/10.1016/j.jbspin.2004.03.009
Publication status	Published - Jan 2005

Keywords

Animals
Arthritis, Rheumatoid
Cell Communication
Chronic Disease
Humans
Leukocytes
Stromal Cells
Synovitis

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10.1016/j.jbspin.2004.03.009

Burman Haworth et al ukmss-35690
NOTICE: this is the author’s version of a work that was accepted for publication in Joint Bone Spine. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Joint Bone Spine, Vol 72, Issue 1, DOI: 10.1016/j.jbspin.2004.03.009
Accepted author manuscript, 816 KBLicence: None: All rights reserved

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abstract = "Rheumatoid arthritis (RA) is a debilitating, chronic, persistent inflammatory disease that is characterised by painful and swollen joints. The aetiology of RA is unknown, however whereas past research has concentrated on the role of immune or inflammatory infiltrating cells in inflammation, it is becoming clear that stromal cells play a critical part in regulating the quality and duration of an inflammatory response. In this review we assess the role of fibroblasts within the inflamed synovium in modulating immune responses; in particular we examine the role of stromal cells in the switch from resolving to persistent inflammation as is found in the rheumatoid synovium.",

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AU - Amft, Esther

AU - Salmon, Michael

AU - Buckley, Christopher D

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The role of leukocyte-stromal interactions in chronic inflammatory joint disease

Abstract

Keywords

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