The role of ITAM- and ITIM-coupled receptors in platelet activation by collagen

Research output: Contribution to journalReview article

Authors

  • N Asazuma
  • D Best
  • R Bobe
  • G Jarvis
  • S Marshall
  • D Snell
  • M Stafford
  • D Tulasne
  • Johnathan Wilde
  • P Wonerow

Abstract

The major activation-inducing collagen receptor glycoprotein VI (GPVI) has been cloned within the last two years. It is a member of the Ig superfamily of proteins and is constitutively associated with the ITAM-bearing Fc receptor gamma-chain (FcR gamma-chain). GPVI signals through a pathway that involves several of the proteins used by Fc, B- and T-lymphocyte receptors and which takes place in glycolipid-enriched membrane domains in the plasma membrane known as GEMs. Responses to GPVI are regulated by PECAM-1 (CD31) and possibly other ITIM-bearing receptors. Despite a pivotal role for GPVI, there are important differences between signalling events to collagen and GPVI-specific ligands. This may reflect a role for co-receptors in the response to collagen.

Details

Original languageEnglish
Pages (from-to)276-88
Number of pages13
JournalJournal of Thrombosis and Haemostasis
Volume86
Issue number1
Publication statusPublished - 1 Jul 2001