Abstract
We have investigated the role of reduced glutathione (GSH) in the genetic toxicity of the rodent renal carcinogen potassium bromate (KBrO(3)). A statistically significant increase in the concentration of 8-oxodeoxyguanosine (8-oxodG) relative to deoxyguanosine was measured following incubation of calf thymus DNA with KBrO(3) and GSH or N-acetylcysteine (NACys). This was dependent on these thiols and was associated with the loss of GSH and production of oxidized glutathione. A short-lived (
| Original language | English |
|---|---|
| Pages (from-to) | 311-316 |
| Number of pages | 6 |
| Journal | Mutagenesis |
| Volume | 15 |
| Issue number | 4 |
| Publication status | Published - Jul 2000 |
Keywords
- Bromates
- Animals
- Chlorates
- DNA Damage
- Glutathione
- Humans
- Carcinogens
- Deoxyguanosine
- Chromatography, High Pressure Liquid
- Glutathione Disulfide
- Potassium Compounds
- Rats
- Acetylcysteine
- Iodates
- Time Factors
- Comet Assay
- Free Radicals
- Leukocytes
- Cattle
- Sulfhydryl Compounds
- Epithelial Cells
- Electron Spin Resonance Spectroscopy
- Thymus Gland
- DNA
- Kidney
- Cell Line