The Role of Eif6 in Skeletal Muscle Homeostasis Revealed by Endurance Training Co-expression Networks

Research output: Contribution to journalArticle

Standard

The Role of Eif6 in Skeletal Muscle Homeostasis Revealed by Endurance Training Co-expression Networks. / Clarke, Kim; Ricciardi, Sara; Pearson, Tim; Bharudin, Izwan; Davidsen, Peter K.; Bonomo, Michela; Brina, Daniela; Scagliola, Alessandra; Simpson, Deborah M.; Beynon, Robert J.; Khanim, Farhat; Ankers, John; Sarzynski, Mark A.; Ghosh, Sujoy; Pisconti, Addolorata; Rozman, Jan; Hrabe de Angelis, Martin; Bunce, Chris; Stewart, Claire; Egginton, Stuart; Caddick, Mark; Jackson, Malcolm; Bouchard, Claude; Biffo, Stefano; Falciani, Francesco.

In: Cell Reports, Vol. 21, No. 6, 07.11.2017, p. 1507-1520.

Research output: Contribution to journalArticle

Harvard

Clarke, K, Ricciardi, S, Pearson, T, Bharudin, I, Davidsen, PK, Bonomo, M, Brina, D, Scagliola, A, Simpson, DM, Beynon, RJ, Khanim, F, Ankers, J, Sarzynski, MA, Ghosh, S, Pisconti, A, Rozman, J, Hrabe de Angelis, M, Bunce, C, Stewart, C, Egginton, S, Caddick, M, Jackson, M, Bouchard, C, Biffo, S & Falciani, F 2017, 'The Role of Eif6 in Skeletal Muscle Homeostasis Revealed by Endurance Training Co-expression Networks', Cell Reports, vol. 21, no. 6, pp. 1507-1520. https://doi.org/10.1016/j.celrep.2017.10.040

APA

Clarke, K., Ricciardi, S., Pearson, T., Bharudin, I., Davidsen, P. K., Bonomo, M., Brina, D., Scagliola, A., Simpson, D. M., Beynon, R. J., Khanim, F., Ankers, J., Sarzynski, M. A., Ghosh, S., Pisconti, A., Rozman, J., Hrabe de Angelis, M., Bunce, C., Stewart, C., ... Falciani, F. (2017). The Role of Eif6 in Skeletal Muscle Homeostasis Revealed by Endurance Training Co-expression Networks. Cell Reports, 21(6), 1507-1520. https://doi.org/10.1016/j.celrep.2017.10.040

Vancouver

Clarke K, Ricciardi S, Pearson T, Bharudin I, Davidsen PK, Bonomo M et al. The Role of Eif6 in Skeletal Muscle Homeostasis Revealed by Endurance Training Co-expression Networks. Cell Reports. 2017 Nov 7;21(6):1507-1520. https://doi.org/10.1016/j.celrep.2017.10.040

Author

Clarke, Kim ; Ricciardi, Sara ; Pearson, Tim ; Bharudin, Izwan ; Davidsen, Peter K. ; Bonomo, Michela ; Brina, Daniela ; Scagliola, Alessandra ; Simpson, Deborah M. ; Beynon, Robert J. ; Khanim, Farhat ; Ankers, John ; Sarzynski, Mark A. ; Ghosh, Sujoy ; Pisconti, Addolorata ; Rozman, Jan ; Hrabe de Angelis, Martin ; Bunce, Chris ; Stewart, Claire ; Egginton, Stuart ; Caddick, Mark ; Jackson, Malcolm ; Bouchard, Claude ; Biffo, Stefano ; Falciani, Francesco. / The Role of Eif6 in Skeletal Muscle Homeostasis Revealed by Endurance Training Co-expression Networks. In: Cell Reports. 2017 ; Vol. 21, No. 6. pp. 1507-1520.

Bibtex

@article{b1d9750d8ea14b3e898ecd1d4c183014,
title = "The Role of Eif6 in Skeletal Muscle Homeostasis Revealed by Endurance Training Co-expression Networks",
abstract = "Regular endurance training improves muscle oxidative capacity and reduces the risk of age-related disorders. Understanding the molecular networks underlying this phenomenon is crucial. Here, by exploiting the power of computational modeling, we show that endurance training induces profound changes in gene regulatory networks linking signaling and selective control of translation to energy metabolism and tissue remodeling. We discovered that knockdown of the mTOR-independent factor Eif6, which we predicted to be a key regulator of this process, affects mitochondrial respiration efficiency, ROS production, and exercise performance. Our work demonstrates the validity of a data-driven approach to understanding muscle homeostasis.",
keywords = "Journal Article, skeletal muscle exercise Eif6 , systems biology , metabolism , mitochondria , network biology",
author = "Kim Clarke and Sara Ricciardi and Tim Pearson and Izwan Bharudin and Davidsen, {Peter K.} and Michela Bonomo and Daniela Brina and Alessandra Scagliola and Simpson, {Deborah M.} and Beynon, {Robert J.} and Farhat Khanim and John Ankers and Sarzynski, {Mark A.} and Sujoy Ghosh and Addolorata Pisconti and Jan Rozman and {Hrabe de Angelis}, Martin and Chris Bunce and Claire Stewart and Stuart Egginton and Mark Caddick and Malcolm Jackson and Claude Bouchard and Stefano Biffo and Francesco Falciani",
note = "Copyright {\textcopyright} 2017 The Authors. Published by Elsevier Inc. All rights reserved.",
year = "2017",
month = nov,
day = "7",
doi = "10.1016/j.celrep.2017.10.040",
language = "English",
volume = "21",
pages = "1507--1520",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Elsevier",
number = "6",

}

RIS

TY - JOUR

T1 - The Role of Eif6 in Skeletal Muscle Homeostasis Revealed by Endurance Training Co-expression Networks

AU - Clarke, Kim

AU - Ricciardi, Sara

AU - Pearson, Tim

AU - Bharudin, Izwan

AU - Davidsen, Peter K.

AU - Bonomo, Michela

AU - Brina, Daniela

AU - Scagliola, Alessandra

AU - Simpson, Deborah M.

AU - Beynon, Robert J.

AU - Khanim, Farhat

AU - Ankers, John

AU - Sarzynski, Mark A.

AU - Ghosh, Sujoy

AU - Pisconti, Addolorata

AU - Rozman, Jan

AU - Hrabe de Angelis, Martin

AU - Bunce, Chris

AU - Stewart, Claire

AU - Egginton, Stuart

AU - Caddick, Mark

AU - Jackson, Malcolm

AU - Bouchard, Claude

AU - Biffo, Stefano

AU - Falciani, Francesco

N1 - Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2017/11/7

Y1 - 2017/11/7

N2 - Regular endurance training improves muscle oxidative capacity and reduces the risk of age-related disorders. Understanding the molecular networks underlying this phenomenon is crucial. Here, by exploiting the power of computational modeling, we show that endurance training induces profound changes in gene regulatory networks linking signaling and selective control of translation to energy metabolism and tissue remodeling. We discovered that knockdown of the mTOR-independent factor Eif6, which we predicted to be a key regulator of this process, affects mitochondrial respiration efficiency, ROS production, and exercise performance. Our work demonstrates the validity of a data-driven approach to understanding muscle homeostasis.

AB - Regular endurance training improves muscle oxidative capacity and reduces the risk of age-related disorders. Understanding the molecular networks underlying this phenomenon is crucial. Here, by exploiting the power of computational modeling, we show that endurance training induces profound changes in gene regulatory networks linking signaling and selective control of translation to energy metabolism and tissue remodeling. We discovered that knockdown of the mTOR-independent factor Eif6, which we predicted to be a key regulator of this process, affects mitochondrial respiration efficiency, ROS production, and exercise performance. Our work demonstrates the validity of a data-driven approach to understanding muscle homeostasis.

KW - Journal Article

KW - skeletal muscle exercise Eif6

KW - systems biology

KW - metabolism

KW - mitochondria

KW - network biology

U2 - 10.1016/j.celrep.2017.10.040

DO - 10.1016/j.celrep.2017.10.040

M3 - Article

C2 - 29117557

VL - 21

SP - 1507

EP - 1520

JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

IS - 6

ER -