TY - JOUR
T1 - The role of cellular flice inhibitory protecin (c-FLIP) in the pathogenesis and treatment of cancer
AU - Dutton, Amanda
AU - Young, Lawrence
AU - Murray, Paul
PY - 2006/2/1
Y1 - 2006/2/1
N2 - Protection from death receptor (DR)-mediated apoptosis has been proposed as an important step in the development of malignancy, enabling tumour cells not only to survive and escape antitumour immune responses, but also to develop resistance to chemotherapy or other cancer treatments. An important regulator of DR-induced death is the cellular FADD-like IL-1 beta-converting enzyme inhibitory protein (c-FLIP) which, when overexpressed, can protect tumour cells from apoptosis. This review focuses on the role of c-FLIP as a tumour progression factor, with particular emphasis on recent work from the authors' laboratory concerning the contribution of c-FLIP to the pathogenesis of Hodgkin's lymphoma. The possibility of targeting c-FLIP as an approach to the treatment of cancer and, in particular, Hodgkin's lymphoma is discussed.
AB - Protection from death receptor (DR)-mediated apoptosis has been proposed as an important step in the development of malignancy, enabling tumour cells not only to survive and escape antitumour immune responses, but also to develop resistance to chemotherapy or other cancer treatments. An important regulator of DR-induced death is the cellular FADD-like IL-1 beta-converting enzyme inhibitory protein (c-FLIP) which, when overexpressed, can protect tumour cells from apoptosis. This review focuses on the role of c-FLIP as a tumour progression factor, with particular emphasis on recent work from the authors' laboratory concerning the contribution of c-FLIP to the pathogenesis of Hodgkin's lymphoma. The possibility of targeting c-FLIP as an approach to the treatment of cancer and, in particular, Hodgkin's lymphoma is discussed.
KW - gene therapy
KW - cellular flice inhibitory protein (c-FLIP)
KW - Hodgkin's lymphoma (HL)
KW - RNA interference
UR - http://www.scopus.com/inward/record.url?scp=33144481343&partnerID=8YFLogxK
U2 - 10.1517/14728222.10.1.27
DO - 10.1517/14728222.10.1.27
M3 - Review article
C2 - 16441226
SN - 1744-7631
SN - 1744-7631
SN - 1744-7631
SN - 1744-7631
VL - 10
SP - 27
EP - 35
JO - Expert Opinion on Therapeutic Targets
JF - Expert Opinion on Therapeutic Targets
ER -