The role of bone marrow-derived cells in venous thromboembolism

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The role of bone marrow-derived cells in venous thromboembolism. / Campos, Joana; Brill, Alexander.

In: The International Journal of Biochemistry & Cell Biology, Vol. 128, 105850, 11.2020.

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@article{381d8475b76d43bab45639ee2d9ba97e,
title = "The role of bone marrow-derived cells in venous thromboembolism",
abstract = "Venous thrombosis is a life-threatening condition with high morbidity and mortality. Abnormal functioning of different cells in the blood is an integral part of its pathogenesis. In this review, we describe the contribution of bone marrow-derived cells to the development of this debilitating disease. We present both epidemiological and clinical data demonstrating involvement of various cell types in venous thrombosis, and discuss potential mechanisms underlying these effects. Modern concepts including recently discovered new paradigms in thrombosis, such as neutrophil extracellular traps, mast cells, and polyphosphate, are summarized.",
keywords = "Deep vein thrombosis, Platelets, Neutrophils, Monocytes, Lymphocytes, Red blood cells, ast cells",
author = "Joana Campos and Alexander Brill",
year = "2020",
month = nov,
doi = "10.1016/j.biocel.2020.105850",
language = "English",
volume = "128",
journal = "The International Journal of Biochemistry & Cell Biology",
issn = "1357-2725",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - The role of bone marrow-derived cells in venous thromboembolism

AU - Campos, Joana

AU - Brill, Alexander

PY - 2020/11

Y1 - 2020/11

N2 - Venous thrombosis is a life-threatening condition with high morbidity and mortality. Abnormal functioning of different cells in the blood is an integral part of its pathogenesis. In this review, we describe the contribution of bone marrow-derived cells to the development of this debilitating disease. We present both epidemiological and clinical data demonstrating involvement of various cell types in venous thrombosis, and discuss potential mechanisms underlying these effects. Modern concepts including recently discovered new paradigms in thrombosis, such as neutrophil extracellular traps, mast cells, and polyphosphate, are summarized.

AB - Venous thrombosis is a life-threatening condition with high morbidity and mortality. Abnormal functioning of different cells in the blood is an integral part of its pathogenesis. In this review, we describe the contribution of bone marrow-derived cells to the development of this debilitating disease. We present both epidemiological and clinical data demonstrating involvement of various cell types in venous thrombosis, and discuss potential mechanisms underlying these effects. Modern concepts including recently discovered new paradigms in thrombosis, such as neutrophil extracellular traps, mast cells, and polyphosphate, are summarized.

KW - Deep vein thrombosis

KW - Platelets

KW - Neutrophils

KW - Monocytes

KW - Lymphocytes

KW - Red blood cells

KW - ast cells

U2 - 10.1016/j.biocel.2020.105850

DO - 10.1016/j.biocel.2020.105850

M3 - Article

VL - 128

JO - The International Journal of Biochemistry & Cell Biology

JF - The International Journal of Biochemistry & Cell Biology

SN - 1357-2725

M1 - 105850

ER -