The role of beta cell heterogeneity in islet function and insulin release

Research output: Contribution to journalArticle

Colleges, School and Institutes

Abstract

It is becoming increasingly apparent that not all insulin-secreting beta cells are equal. Subtle differences exist at the transcriptomic and protein expression levels, with repercussions for beta cell survival/proliferation, calcium signalling and insulin release. Notably, beta cell heterogeneity displays plasticity during development, metabolic stress and type 2 diabetes mellitus (T2DM). Thus, heterogeneity or lack thereof may be an important contributor to beta cell failure during T2DM in both rodents and humans. The present review will discuss the molecular and cellular features of beta cell heterogeneity at both the single-cell and islet level, explore how this influences islet function and insulin release, and look into the alterations that may occur during obesity and T2DM.

Details

Original languageEnglish
Pages (from-to)R43-R60
Number of pages18
JournalJournal of Molecular Endocrinology
Volume61
Early online date16 Apr 2018
Publication statusPublished - 1 Jul 2018