The role of B lymphocytes in the immuno-biology of non-small-cell lung cancer

Akshay J. Patel; Alex Richter; Mark T. Drayson; Gary W. Middleton

doi:10.1007/s00262-019-02461-2

The role of B lymphocytes in the immuno-biology of non-small-cell lung cancer

Akshay J. Patel, Alex Richter, Mark T. Drayson, Gary W. Middleton

Immunology and Immunotherapy

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

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Abstract

Tumour-infiltrating immune cells have been widely implicated to play a significant role in carcinogenesis, through both pro- or anti-tumour effects. The multi-faceted effects of lung cancer associated T lymphocytes have been extensively studied, and yet, the role of B lymphocytes remains an area less studied. In this review, we will describe the current understanding of the role of tumour-infiltrating B lymphocytes in NSCLC, discuss their prognostic significance, their functionality within the tumour microenvironment and ultimately how we might harness B-cell biology to develop B-cell therapeutic strategies in cancer.

Original language	English
Pages (from-to)	325-342
Journal	Cancer Immunology Immunotherapy
Volume	69
Issue number	3
Early online date	4 Jan 2020
DOIs	https://doi.org/10.1007/s00262-019-02461-2
Publication status	E-pub ahead of print - 4 Jan 2020

Keywords

B lymphocyte
Humoral Immunity
Immunoglobulin
Non-small-cell lung cancer (NSCLC)
Tumour -infiltrating B lymphocyte (TIL-B)

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Patel_Richter_Drayson&Middleton_Role_B_lymphocytes_Cancer_Immunology_Immunotherapy_2020Final published version, 574 KBLicence: Creative Commons: Attribution (CC BY)

http://link.springer.com/10.1007/s00262-019-02461-2

Cite this

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title = "The role of B lymphocytes in the immuno-biology of non-small-cell lung cancer",

abstract = "Tumour-infiltrating immune cells have been widely implicated to play a significant role in carcinogenesis, through both pro- or anti-tumour effects. The multi-faceted effects of lung cancer associated T lymphocytes have been extensively studied, and yet, the role of B lymphocytes remains an area less studied. In this review, we will describe the current understanding of the role of tumour-infiltrating B lymphocytes in NSCLC, discuss their prognostic significance, their functionality within the tumour microenvironment and ultimately how we might harness B-cell biology to develop B-cell therapeutic strategies in cancer.",

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AU - Patel, Akshay J.

AU - Richter, Alex

AU - Drayson, Mark T.

AU - Middleton, Gary W.

PY - 2020/1/4

Y1 - 2020/1/4

N2 - Tumour-infiltrating immune cells have been widely implicated to play a significant role in carcinogenesis, through both pro- or anti-tumour effects. The multi-faceted effects of lung cancer associated T lymphocytes have been extensively studied, and yet, the role of B lymphocytes remains an area less studied. In this review, we will describe the current understanding of the role of tumour-infiltrating B lymphocytes in NSCLC, discuss their prognostic significance, their functionality within the tumour microenvironment and ultimately how we might harness B-cell biology to develop B-cell therapeutic strategies in cancer.

AB - Tumour-infiltrating immune cells have been widely implicated to play a significant role in carcinogenesis, through both pro- or anti-tumour effects. The multi-faceted effects of lung cancer associated T lymphocytes have been extensively studied, and yet, the role of B lymphocytes remains an area less studied. In this review, we will describe the current understanding of the role of tumour-infiltrating B lymphocytes in NSCLC, discuss their prognostic significance, their functionality within the tumour microenvironment and ultimately how we might harness B-cell biology to develop B-cell therapeutic strategies in cancer.

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KW - Humoral Immunity

KW - Immunoglobulin

KW - Non-small-cell lung cancer (NSCLC)

KW - Tumour -infiltrating B lymphocyte (TIL-B)

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VL - 69

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JF - Cancer Immunology Immunotherapy

IS - 3

ER -

The role of B lymphocytes in the immuno-biology of non-small-cell lung cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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