Abstract
Tumour-infiltrating immune cells have been widely implicated to play a significant role in carcinogenesis, through both pro- or anti-tumour effects. The multi-faceted effects of lung cancer associated T lymphocytes have been extensively studied, and yet, the role of B lymphocytes remains an area less studied. In this review, we will describe the current understanding of the role of tumour-infiltrating B lymphocytes in NSCLC, discuss their prognostic significance, their functionality within the tumour microenvironment and ultimately how we might harness B-cell biology to develop B-cell therapeutic strategies in cancer.
Original language | English |
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Pages (from-to) | 325-342 |
Journal | Cancer Immunology Immunotherapy |
Volume | 69 |
Issue number | 3 |
Early online date | 4 Jan 2020 |
DOIs | |
Publication status | E-pub ahead of print - 4 Jan 2020 |
Keywords
- B lymphocyte
- Humoral Immunity
- Immunoglobulin
- Non-small-cell lung cancer (NSCLC)
- Tumour -infiltrating B lymphocyte (TIL-B)
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Oncology
- Cancer Research