The role of B lymphocytes in the immuno-biology of non-small-cell lung cancer
Research output: Contribution to journal › Article
Tumour-infiltrating immune cells have been widely implicated to play a significant role in carcinogenesis, through both pro- or anti-tumour effects. The multi-faceted effects of lung cancer associated T lymphocytes have been extensively studied, and yet, the role of B lymphocytes remains an area less studied. In this review, we will describe the current understanding of the role of tumour-infiltrating B lymphocytes in NSCLC, discuss their prognostic significance, their functionality within the tumour microenvironment and ultimately how we might harness B-cell biology to develop B-cell therapeutic strategies in cancer.
|Journal||Cancer Immunology Immunotherapy|
|Early online date||4 Jan 2020|
|Publication status||E-pub ahead of print - 4 Jan 2020|