The response of circulating levels of the interleukin-6/interleukin-6 receptor complex to exercise in young men

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The response of circulating levels of the interleukin-6/interleukin-6 receptor complex to exercise in young men. / Gray, S R; Clifford, M; Lancaster, R; Leggate, M; Davies, M; Nimmo, M A.

In: Cytokine, Vol. 47, No. 2, 08.2009, p. 98-102.

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Gray, S R ; Clifford, M ; Lancaster, R ; Leggate, M ; Davies, M ; Nimmo, M A. / The response of circulating levels of the interleukin-6/interleukin-6 receptor complex to exercise in young men. In: Cytokine. 2009 ; Vol. 47, No. 2. pp. 98-102.

Bibtex

@article{75aedab42acb43cdae5b2d19580d1c31,
title = "The response of circulating levels of the interleukin-6/interleukin-6 receptor complex to exercise in young men",
abstract = "The formation of an interleukin-6/IL-6 receptor (IL-6/IL-6R) complex increases the biological activity and half-life of IL-6, with its response to exercise currently unknown. The aim of the present study was to determine the response of circulating levels of the IL-6/IL-6R complex to exercise. Nine healthy male participants performed 1h of cycling exercise at a workload required to elicit 90% lactate threshold. Venous blood samples were taken at rest, immediately post-exercise and after 1.5 h rest. Hemoglobin concentration and hematocrit were measured to estimate changes in plasma volume during exercise. The concentrations of IL-6, sIL-6R and the IL-6/IL-6R complex were measured via ELISA and corrected for changes in plasma volume. A single bout of acute exercise resulted in a 5-fold increase (P<0.05) in IL-6 and a 1.2-fold increase (P<0.05) in sIL-6R immediately after exercise. These returned to baseline at 1.5 h after the cessation of exercise. There was a 2.1-fold increase (P<0.05) in the levels of the IL-6/IL-6R complex post-exercise with levels remaining 1.8 times elevated (P<0.05) after 1.5 h rest. The present study has demonstrated, for the first time, that circulating levels of the IL-6/IL-6R complex are increased in response to acute exercise in young males.",
keywords = "Adult, Exercise, Humans, Interleukin-6, Male, Receptors, Interleukin-6",
author = "Gray, {S R} and M Clifford and R Lancaster and M Leggate and M Davies and Nimmo, {M A}",
year = "2009",
month = aug,
doi = "10.1016/j.cyto.2009.05.011",
language = "English",
volume = "47",
pages = "98--102",
journal = "Cytokine",
issn = "1043-4666",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - The response of circulating levels of the interleukin-6/interleukin-6 receptor complex to exercise in young men

AU - Gray, S R

AU - Clifford, M

AU - Lancaster, R

AU - Leggate, M

AU - Davies, M

AU - Nimmo, M A

PY - 2009/8

Y1 - 2009/8

N2 - The formation of an interleukin-6/IL-6 receptor (IL-6/IL-6R) complex increases the biological activity and half-life of IL-6, with its response to exercise currently unknown. The aim of the present study was to determine the response of circulating levels of the IL-6/IL-6R complex to exercise. Nine healthy male participants performed 1h of cycling exercise at a workload required to elicit 90% lactate threshold. Venous blood samples were taken at rest, immediately post-exercise and after 1.5 h rest. Hemoglobin concentration and hematocrit were measured to estimate changes in plasma volume during exercise. The concentrations of IL-6, sIL-6R and the IL-6/IL-6R complex were measured via ELISA and corrected for changes in plasma volume. A single bout of acute exercise resulted in a 5-fold increase (P<0.05) in IL-6 and a 1.2-fold increase (P<0.05) in sIL-6R immediately after exercise. These returned to baseline at 1.5 h after the cessation of exercise. There was a 2.1-fold increase (P<0.05) in the levels of the IL-6/IL-6R complex post-exercise with levels remaining 1.8 times elevated (P<0.05) after 1.5 h rest. The present study has demonstrated, for the first time, that circulating levels of the IL-6/IL-6R complex are increased in response to acute exercise in young males.

AB - The formation of an interleukin-6/IL-6 receptor (IL-6/IL-6R) complex increases the biological activity and half-life of IL-6, with its response to exercise currently unknown. The aim of the present study was to determine the response of circulating levels of the IL-6/IL-6R complex to exercise. Nine healthy male participants performed 1h of cycling exercise at a workload required to elicit 90% lactate threshold. Venous blood samples were taken at rest, immediately post-exercise and after 1.5 h rest. Hemoglobin concentration and hematocrit were measured to estimate changes in plasma volume during exercise. The concentrations of IL-6, sIL-6R and the IL-6/IL-6R complex were measured via ELISA and corrected for changes in plasma volume. A single bout of acute exercise resulted in a 5-fold increase (P<0.05) in IL-6 and a 1.2-fold increase (P<0.05) in sIL-6R immediately after exercise. These returned to baseline at 1.5 h after the cessation of exercise. There was a 2.1-fold increase (P<0.05) in the levels of the IL-6/IL-6R complex post-exercise with levels remaining 1.8 times elevated (P<0.05) after 1.5 h rest. The present study has demonstrated, for the first time, that circulating levels of the IL-6/IL-6R complex are increased in response to acute exercise in young males.

KW - Adult

KW - Exercise

KW - Humans

KW - Interleukin-6

KW - Male

KW - Receptors, Interleukin-6

U2 - 10.1016/j.cyto.2009.05.011

DO - 10.1016/j.cyto.2009.05.011

M3 - Article

C2 - 19527938

VL - 47

SP - 98

EP - 102

JO - Cytokine

JF - Cytokine

SN - 1043-4666

IS - 2

ER -