The relationship between albuminuria, MCP-1/CCL2 and interstitial macrophages in chronic kidney disease

Research output: Contribution to journalArticle

Authors

  • KS Eardley
  • D Zehnder
  • MO Quinkler
  • J Lepenies
  • AJ Howie
  • Dwomoa Adu
  • Paul Cockwell

Abstract

Glomerular-derived proteins may activate tubular cells to express the macrophage-directed chemokine monocyte chemoattractant protein-1 (MCP-1/CCL2). Macrophages at interstitial sites have a central role in directing renal scarring. We have prospectively assessed the relationship between albuminuria, urinary MCP-1/CCL2, interstitial macrophage infiltration, in situ damage, and clinical outcomes in a large group of patients with chronic kidney disease. We studied 215 patients and quantified albumin-creatinine ratio (ACR), urinary MCP-1/CCL2, interstitial macrophage numbers, and in situ damage. ACR correlated with urinary MCP-1/CCL2 (correlation 0.499; P

Details

Original languageEnglish
Pages (from-to)1189-1197
Number of pages9
JournalKidney International
Volume69
Publication statusPublished - 15 Feb 2006