The psychopathology and neuroanatomical markers of depression in early psychosis

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The psychopathology and neuroanatomical markers of depression in early psychosis. / PRONIA Consortium.

In: Schizophrenia bulletin, Vol. 2020, sbaa094, 07.07.2020.

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@article{072d3f5c547a4344ad42d68c6ec9edbb,
title = "The psychopathology and neuroanatomical markers of depression in early psychosis",
abstract = "Depression frequently occurs in first-episode psychosis (FEP) and predicts longer-term negative outcomes. It is possible that this depression is seen primarily in a distinct subgroup, which if identified could allow targeted treatments. We hypothesize that patients with recent-onset psychosis (ROP) and comorbid depression would be identifiable by symptoms and neuroanatomical features similar to those seen in recent-onset depression (ROD). Data were extracted from the multisite PRONIA study: 154 ROP patients (FEP within 3 months of treatment onset), of whom 83 were depressed (ROP+D) and 71 who were not depressed (ROP−D), 146 ROD patients, and 265 healthy controls (HC). Analyses included a (1) principal component analysis that established the similar symptom structure of depression in ROD and ROP+D, (2) supervised machine learning (ML) classification with repeated nested cross-validation based on depressive symptoms separating ROD vs ROP+D, which achieved a balanced accuracy (BAC) of 51%, and (3) neuroanatomical ML-based classification, using regions of interest generated from ROD subjects, which identified BAC of 50% (no better than chance) for separation of ROP+D vs ROP−D. We conclude that depression at a symptom level is broadly similar with or without psychosis status in recent-onset disorders; however, this is not driven by a separable depressed subgroup in FEP. Depression may be intrinsic to early stages of psychotic disorder, and thus treating depression could produce widespread benefit.",
keywords = "schizophrenia, psychosis, depression, gray matter volume, psychopathology, machine learning",
author = "{PRONIA Consortium} and Rachel Upthegrove and Lalousis, {Paris Alexandros} and Pavan Mallikarjun and Katie Chisholm and Lowri Griffiths and Mariam Iqbal and Mirabel Pelton and Renate Reniers and Alexandra Stainton and Marlene Rosen and A. Ruef and Dominic Dwyer and Surman Marian and Nora Penzal and Lana Kambietz and Bertolino Alessasandro and Paolo Brambillo and Stefan Borgwardt and Joseph Kambietz and Rebekka Lencer and C Pantelis and S Ruhrmann and {Schultze Lutter}, F and Salokangas, {R. K.R.} and Eva Meisenzahl and Stephen Wood and Nikolaos Koutsouleris",
year = "2020",
month = jul,
day = "7",
doi = "10.1093/schbul/sbaa094",
language = "English",
volume = "2020",
journal = "Schizophrenia bulletin",
issn = "0586-7614",
publisher = "Oxford University Press",

}

RIS

TY - JOUR

T1 - The psychopathology and neuroanatomical markers of depression in early psychosis

AU - PRONIA Consortium

AU - Upthegrove, Rachel

AU - Lalousis, Paris Alexandros

AU - Mallikarjun, Pavan

AU - Chisholm, Katie

AU - Griffiths, Lowri

AU - Iqbal, Mariam

AU - Pelton, Mirabel

AU - Reniers, Renate

AU - Stainton, Alexandra

AU - Rosen, Marlene

AU - Ruef, A.

AU - Dwyer, Dominic

AU - Marian, Surman

AU - Penzal, Nora

AU - Kambietz, Lana

AU - Alessasandro, Bertolino

AU - Brambillo, Paolo

AU - Borgwardt, Stefan

AU - Kambietz, Joseph

AU - Lencer, Rebekka

AU - Pantelis, C

AU - Ruhrmann, S

AU - Schultze Lutter, F

AU - Salokangas, R. K.R.

AU - Meisenzahl, Eva

AU - Wood, Stephen

AU - Koutsouleris, Nikolaos

PY - 2020/7/7

Y1 - 2020/7/7

N2 - Depression frequently occurs in first-episode psychosis (FEP) and predicts longer-term negative outcomes. It is possible that this depression is seen primarily in a distinct subgroup, which if identified could allow targeted treatments. We hypothesize that patients with recent-onset psychosis (ROP) and comorbid depression would be identifiable by symptoms and neuroanatomical features similar to those seen in recent-onset depression (ROD). Data were extracted from the multisite PRONIA study: 154 ROP patients (FEP within 3 months of treatment onset), of whom 83 were depressed (ROP+D) and 71 who were not depressed (ROP−D), 146 ROD patients, and 265 healthy controls (HC). Analyses included a (1) principal component analysis that established the similar symptom structure of depression in ROD and ROP+D, (2) supervised machine learning (ML) classification with repeated nested cross-validation based on depressive symptoms separating ROD vs ROP+D, which achieved a balanced accuracy (BAC) of 51%, and (3) neuroanatomical ML-based classification, using regions of interest generated from ROD subjects, which identified BAC of 50% (no better than chance) for separation of ROP+D vs ROP−D. We conclude that depression at a symptom level is broadly similar with or without psychosis status in recent-onset disorders; however, this is not driven by a separable depressed subgroup in FEP. Depression may be intrinsic to early stages of psychotic disorder, and thus treating depression could produce widespread benefit.

AB - Depression frequently occurs in first-episode psychosis (FEP) and predicts longer-term negative outcomes. It is possible that this depression is seen primarily in a distinct subgroup, which if identified could allow targeted treatments. We hypothesize that patients with recent-onset psychosis (ROP) and comorbid depression would be identifiable by symptoms and neuroanatomical features similar to those seen in recent-onset depression (ROD). Data were extracted from the multisite PRONIA study: 154 ROP patients (FEP within 3 months of treatment onset), of whom 83 were depressed (ROP+D) and 71 who were not depressed (ROP−D), 146 ROD patients, and 265 healthy controls (HC). Analyses included a (1) principal component analysis that established the similar symptom structure of depression in ROD and ROP+D, (2) supervised machine learning (ML) classification with repeated nested cross-validation based on depressive symptoms separating ROD vs ROP+D, which achieved a balanced accuracy (BAC) of 51%, and (3) neuroanatomical ML-based classification, using regions of interest generated from ROD subjects, which identified BAC of 50% (no better than chance) for separation of ROP+D vs ROP−D. We conclude that depression at a symptom level is broadly similar with or without psychosis status in recent-onset disorders; however, this is not driven by a separable depressed subgroup in FEP. Depression may be intrinsic to early stages of psychotic disorder, and thus treating depression could produce widespread benefit.

KW - schizophrenia

KW - psychosis

KW - depression

KW - gray matter volume

KW - psychopathology

KW - machine learning

U2 - 10.1093/schbul/sbaa094

DO - 10.1093/schbul/sbaa094

M3 - Article

VL - 2020

JO - Schizophrenia bulletin

JF - Schizophrenia bulletin

SN - 0586-7614

M1 - sbaa094

ER -