The ProTides Boom

Youcef Mehellou

doi:10.1002/cmdc.201600156

The ProTides Boom

Youcef Mehellou

Pharmacy

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Abstract

The masking of nucleoside phosphate and phosphonate groups by an aryl motif and an amino acid ester, nowadays known as the ‘ProTide’ technology, has proven to be effective in the discovery of nucleotide therapeutics. Indeed, this technology, which was invented by Chris McGuigan in the early 1990s, has inspired the discovery of two FDA-approved antiviral nucleotide drugs, and many more are currently undergoing (pre)clinical development. The usefulness of this technology in the discovery of nucleotide therapeutics is showcased in this Highlight by discussing the ProTides development and the various ProTides that have reached clinical trials

Original language	English
Journal	ChemMedChem
Early online date	9 May 2016
DOIs	https://doi.org/10.1002/cmdc.201600156
Publication status	E-pub ahead of print - 9 May 2016

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10.1002/cmdc.201600156Licence: None: All rights reserved

Mehellou_ProTides_boom_ChemMedChem_2016
Checked for eligibility: 20/05/2016. This is the peer reviewed version of the following article: Mehellou, Youcef. "The ProTides Boom." ChemMedChem (2016). , which has been published in final form at DOI:10.1002/cmdc.201600156 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
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The ProTides Boom

Abstract

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