The Protein Corona Mediates the Impact of Nanomaterials and Slows Amyloid Beta Fibrillation

Research output: Contribution to journalArticle

Authors

  • M. Mahmoudi
  • M. Rezaei
  • M.P. Monopoli
  • F. Bertoli
  • K.A. Dawson
  • J.J. Mcmanus

Colleges, School and Institutes

External organisations

  • UNIVERSITY COLLEGE DUBLIN
  • Tehran University of Medical Sciences
  • National University of Ireland Maynooth

Abstract

Put your coat on: It is well recognized that the surfaces of nanomaterials in biological media are covered by various biomolecules (e.g., proteins). A) The protein corona creates a shell over different nanomaterials, regardless of their physicochemical properties (e.g., composition and shape), resulting in reduced levels of amyloid beta fibril formation. B) Pristine nanomaterials might have acceleratory effects on the fibrillation of amyloid beta.

Bibliographic note

Copyright 2013 Elsevier B.V., All rights reserved.

Details

Original languageEnglish
Pages (from-to)568-572
Number of pages5
JournalChemBioChem
Volume14
Issue number5
Publication statusPublished - 1 Mar 2013