The Profiles and Correlates of Psychopathology in Adolescents and Adults with Williams, Fragile X and Prader–Willi Syndromes

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@article{c6d3846b35444f718d704f3d5b10e737,
title = "The Profiles and Correlates of Psychopathology in Adolescents and Adults with Williams, Fragile X and Prader–Willi Syndromes",
abstract = "Psychopathology is prevalent in Williams (WS), fragile X (FXS) and Prader–Willi (PWS) syndromes. However, little is known about the potential correlates of psychopathology in these groups. A questionnaire study was completed by 111 caregivers of individuals with WS (n = 35); FXS (n = 50) and PWS (n = 26). Mean age was 26 years (range 12–57 years); 74 (67%) were male. Multiple regression analyses indicated that higher rates of health problems and sensory impairments predicted higher psychopathology in WS (p < .0001). In PWS, poorer adaptive ability predicted higher overall psychiatric disturbance (p = .001), generalised anxiety (p = .006) and hyperactivity (p = .003). There were no significant predictors in FXS. This study highlights dissociations in the potential risk markers of psychopathology between genetic syndromes. Implications for intervention are discussed.",
keywords = "Williams syndrome, Prader–Willi syndrome, Fragile X syndrome, Psychopathology, Correlates",
author = "R. Royston and C. Oliver and P. Howlin and A. Dosse and P. Armitage and J. Moss and J. Waite",
year = "2019",
month = dec
day = "4",
doi = "10.1007/s10803-019-04317-1",
language = "English",
pages = "1--11",
journal = "Journal of Autism and Developmental Disorders",
issn = "0162-3257",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - The Profiles and Correlates of Psychopathology in Adolescents and Adults with Williams, Fragile X and Prader–Willi Syndromes

AU - Royston, R.

AU - Oliver, C.

AU - Howlin, P.

AU - Dosse, A.

AU - Armitage, P.

AU - Moss, J.

AU - Waite, J.

PY - 2019/12/4

Y1 - 2019/12/4

N2 - Psychopathology is prevalent in Williams (WS), fragile X (FXS) and Prader–Willi (PWS) syndromes. However, little is known about the potential correlates of psychopathology in these groups. A questionnaire study was completed by 111 caregivers of individuals with WS (n = 35); FXS (n = 50) and PWS (n = 26). Mean age was 26 years (range 12–57 years); 74 (67%) were male. Multiple regression analyses indicated that higher rates of health problems and sensory impairments predicted higher psychopathology in WS (p < .0001). In PWS, poorer adaptive ability predicted higher overall psychiatric disturbance (p = .001), generalised anxiety (p = .006) and hyperactivity (p = .003). There were no significant predictors in FXS. This study highlights dissociations in the potential risk markers of psychopathology between genetic syndromes. Implications for intervention are discussed.

AB - Psychopathology is prevalent in Williams (WS), fragile X (FXS) and Prader–Willi (PWS) syndromes. However, little is known about the potential correlates of psychopathology in these groups. A questionnaire study was completed by 111 caregivers of individuals with WS (n = 35); FXS (n = 50) and PWS (n = 26). Mean age was 26 years (range 12–57 years); 74 (67%) were male. Multiple regression analyses indicated that higher rates of health problems and sensory impairments predicted higher psychopathology in WS (p < .0001). In PWS, poorer adaptive ability predicted higher overall psychiatric disturbance (p = .001), generalised anxiety (p = .006) and hyperactivity (p = .003). There were no significant predictors in FXS. This study highlights dissociations in the potential risk markers of psychopathology between genetic syndromes. Implications for intervention are discussed.

KW - Williams syndrome

KW - Prader–Willi syndrome

KW - Fragile X syndrome

KW - Psychopathology

KW - Correlates

UR - http://www.scopus.com/inward/record.url?scp=85075992834&partnerID=8YFLogxK

U2 - 10.1007/s10803-019-04317-1

DO - 10.1007/s10803-019-04317-1

M3 - Article

SP - 1

EP - 11

JO - Journal of Autism and Developmental Disorders

JF - Journal of Autism and Developmental Disorders

SN - 0162-3257

ER -