The Profiles and Correlates of Psychopathology in Adolescents and Adults with Williams, Fragile X and Prader–Willi Syndromes

Research output: Contribution to journalArticlepeer-review

Authors

  • R. Royston
  • P. Howlin
  • A. Dosse
  • P. Armitage

Colleges, School and Institutes

Abstract

Psychopathology is prevalent in Williams (WS), fragile X (FXS) and Prader–Willi (PWS) syndromes. However, little is known about the potential correlates of psychopathology in these groups. A questionnaire study was completed by 111 caregivers of individuals with WS (n = 35); FXS (n = 50) and PWS (n = 26). Mean age was 26 years (range 12–57 years); 74 (67%) were male. Multiple regression analyses indicated that higher rates of health problems and sensory impairments predicted higher psychopathology in WS (p < .0001). In PWS, poorer adaptive ability predicted higher overall psychiatric disturbance (p = .001), generalised anxiety (p = .006) and hyperactivity (p = .003). There were no significant predictors in FXS. This study highlights dissociations in the potential risk markers of psychopathology between genetic syndromes. Implications for intervention are discussed.

Details

Original languageEnglish
Pages (from-to)1-11
JournalJournal of Autism and Developmental Disorders
Early online date4 Dec 2019
Publication statusE-pub ahead of print - 4 Dec 2019

Keywords

  • Williams syndrome, Prader–Willi syndrome, Fragile X syndrome, Psychopathology, Correlates