The Profiles and Correlates of Psychopathology in Adolescents and Adults with Williams, Fragile X and Prader–Willi Syndromes
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Colleges, School and Institutes
Psychopathology is prevalent in Williams (WS), fragile X (FXS) and Prader–Willi (PWS) syndromes. However, little is known about the potential correlates of psychopathology in these groups. A questionnaire study was completed by 111 caregivers of individuals with WS (n = 35); FXS (n = 50) and PWS (n = 26). Mean age was 26 years (range 12–57 years); 74 (67%) were male. Multiple regression analyses indicated that higher rates of health problems and sensory impairments predicted higher psychopathology in WS (p < .0001). In PWS, poorer adaptive ability predicted higher overall psychiatric disturbance (p = .001), generalised anxiety (p = .006) and hyperactivity (p = .003). There were no significant predictors in FXS. This study highlights dissociations in the potential risk markers of psychopathology between genetic syndromes. Implications for intervention are discussed.
|Journal||Journal of Autism and Developmental Disorders|
|Early online date||4 Dec 2019|
|Publication status||E-pub ahead of print - 4 Dec 2019|
- Williams syndrome, Prader–Willi syndrome, Fragile X syndrome, Psychopathology, Correlates