TY - JOUR
T1 - The prevalence of vitamin D abnormalities in South Asians with type 2 diabetes mellitus in the UK
AU - Tahrani, Abd
AU - Ball, Alexandra
AU - Shepherd, L
AU - Rahim, Asad
AU - Jones, Alan
AU - Bates, Andrew
PY - 2010/2/1
Y1 - 2010/2/1
N2 - P>Background:
The high prevalence of both hypovitaminosis D and type 2 diabetes (T2DM) in the Asian community is well recognised, but the impact of diabetes on vitamin D status and vice versa, has not been well reported.
Aims:
To determine the prevalence of hypovitaminosis D in Asian patients with T2DM and its impact on glycaemic control.
Methods:
A cross-sectional study was conducted in a tertiary referral centre in the UK. Two hundred and ten Asian patients aged more than 40 years were included (170 with and 40 without T2DM). Each had a standard bone profile (serum calcium, phosphate and alkaline phosphatase), serum parathyroid hormone and 25-hydroxycholecalciferol.
Results:
The prevalence of low serum 25-hydroxyvitamin D (<50 nmol/l) was high in the group as a whole (> 80%) and more common in diabetics compared with controls (83% vs. 70%; p = 0.07). This was particularly so in men (82.5% vs. 57.9%; p = 0.02). HbA1c was higher in women with vitamin D deficiency (<12.5 nmol/l) (8.11 +/- 1.11% vs. 7.33 +/- 1.32%, p = 0.046). In logistic regression analysis, T2DM was an independent predictor of hypovitaminosis D. In linear regression analysis, vitamin D deficiency was independently related to HbA1c in women with T2DM.
Conclusions:
Hypovitaminosis D remains a major public health issue in the Asian population and is exaggerated in patients with T2DM. The fact that vitamin D deficient women had higher HbA1c levels raises the possibility that vitamin D replacement may improve glycaemic control.
AB - P>Background:
The high prevalence of both hypovitaminosis D and type 2 diabetes (T2DM) in the Asian community is well recognised, but the impact of diabetes on vitamin D status and vice versa, has not been well reported.
Aims:
To determine the prevalence of hypovitaminosis D in Asian patients with T2DM and its impact on glycaemic control.
Methods:
A cross-sectional study was conducted in a tertiary referral centre in the UK. Two hundred and ten Asian patients aged more than 40 years were included (170 with and 40 without T2DM). Each had a standard bone profile (serum calcium, phosphate and alkaline phosphatase), serum parathyroid hormone and 25-hydroxycholecalciferol.
Results:
The prevalence of low serum 25-hydroxyvitamin D (<50 nmol/l) was high in the group as a whole (> 80%) and more common in diabetics compared with controls (83% vs. 70%; p = 0.07). This was particularly so in men (82.5% vs. 57.9%; p = 0.02). HbA1c was higher in women with vitamin D deficiency (<12.5 nmol/l) (8.11 +/- 1.11% vs. 7.33 +/- 1.32%, p = 0.046). In logistic regression analysis, T2DM was an independent predictor of hypovitaminosis D. In linear regression analysis, vitamin D deficiency was independently related to HbA1c in women with T2DM.
Conclusions:
Hypovitaminosis D remains a major public health issue in the Asian population and is exaggerated in patients with T2DM. The fact that vitamin D deficient women had higher HbA1c levels raises the possibility that vitamin D replacement may improve glycaemic control.
U2 - 10.1111/j.1742-1241.2009.02221.x
DO - 10.1111/j.1742-1241.2009.02221.x
M3 - Article
C2 - 19863680
SN - 1742-1241
VL - 64
SP - 351
EP - 355
JO - International Journal of Clinical Practice
JF - International Journal of Clinical Practice
IS - 3
ER -
