The prevalence of hypopituitarism and its evaluation following traumatic brain injury: Evidence for early screening tools

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The prevalence of hypopituitarism and its evaluation following traumatic brain injury : Evidence for early screening tools. / Rymer, Ben (Contributor); Yip, Kay Por (Contributor); Belli, Antonio.

In: International journal of surgery (London, England), Vol. 12, No. supplement 3, 30.11.2014, p. S53.

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@article{be37339c3d0d43cfafce0e110d358373,
title = "The prevalence of hypopituitarism and its evaluation following traumatic brain injury: Evidence for early screening tools",
abstract = "Introduction: To determine the prevalence of pituitary dysfunction following traumatic brain injury (TBI) and evaluate its assessment.Methods: Data were retrospectively collected on 104 patients admitted to the Wessex Neurological Centre with TBI over 1-year. An electronic TBI database and patient notes were reviewed for endocrinological tests performed, results and deficiencies identified.Results: Only 37.5% (n=39) of patients were assessed for any form of pituitary dysfunction. On average, these assessments only covered 1.9 of 6 clinically relevant pituitary hormones per patient. Of patients tested, 53.8% (n=21) were found to have pituitary dysfunction. ACTH deficiency was found in 47.6% (n=10), diabetes insipidus in 47.6% (n=10), TSH deficiency in 14.3% (n=3). One patient had low gonadotrophins. One case of growth hormone deficiency was noted. Three patients had multiple deficiencies.Conclusions: Only a minority of patients are assessed for hypopituitarism following TBI. Assessments that do occur have inadequate scope. In those assessed, the prevalence of hypopituitarism is high, with multiple hormones affected in some. This may reflect selection bias, if testing is based on clinical suspicion. Given this high prevalence, we recommend the development of screening tools for early detection of pituitary dysfunction following TBI. The relevance of early testing will be discussed.",
author = "Ben Rymer and Yip, {Kay Por} and Antonio Belli",
year = "2014",
month = nov,
day = "30",
doi = "10.1016/j.ijsu.2014.07.244",
language = "English",
volume = "12",
pages = "S53",
journal = "International journal of surgery (London, England)",
issn = "1743-9191",
publisher = "Elsevier",
number = "supplement 3",

}

RIS

TY - JOUR

T1 - The prevalence of hypopituitarism and its evaluation following traumatic brain injury

T2 - Evidence for early screening tools

AU - Belli, Antonio

A2 - Rymer, Ben

A2 - Yip, Kay Por

PY - 2014/11/30

Y1 - 2014/11/30

N2 - Introduction: To determine the prevalence of pituitary dysfunction following traumatic brain injury (TBI) and evaluate its assessment.Methods: Data were retrospectively collected on 104 patients admitted to the Wessex Neurological Centre with TBI over 1-year. An electronic TBI database and patient notes were reviewed for endocrinological tests performed, results and deficiencies identified.Results: Only 37.5% (n=39) of patients were assessed for any form of pituitary dysfunction. On average, these assessments only covered 1.9 of 6 clinically relevant pituitary hormones per patient. Of patients tested, 53.8% (n=21) were found to have pituitary dysfunction. ACTH deficiency was found in 47.6% (n=10), diabetes insipidus in 47.6% (n=10), TSH deficiency in 14.3% (n=3). One patient had low gonadotrophins. One case of growth hormone deficiency was noted. Three patients had multiple deficiencies.Conclusions: Only a minority of patients are assessed for hypopituitarism following TBI. Assessments that do occur have inadequate scope. In those assessed, the prevalence of hypopituitarism is high, with multiple hormones affected in some. This may reflect selection bias, if testing is based on clinical suspicion. Given this high prevalence, we recommend the development of screening tools for early detection of pituitary dysfunction following TBI. The relevance of early testing will be discussed.

AB - Introduction: To determine the prevalence of pituitary dysfunction following traumatic brain injury (TBI) and evaluate its assessment.Methods: Data were retrospectively collected on 104 patients admitted to the Wessex Neurological Centre with TBI over 1-year. An electronic TBI database and patient notes were reviewed for endocrinological tests performed, results and deficiencies identified.Results: Only 37.5% (n=39) of patients were assessed for any form of pituitary dysfunction. On average, these assessments only covered 1.9 of 6 clinically relevant pituitary hormones per patient. Of patients tested, 53.8% (n=21) were found to have pituitary dysfunction. ACTH deficiency was found in 47.6% (n=10), diabetes insipidus in 47.6% (n=10), TSH deficiency in 14.3% (n=3). One patient had low gonadotrophins. One case of growth hormone deficiency was noted. Three patients had multiple deficiencies.Conclusions: Only a minority of patients are assessed for hypopituitarism following TBI. Assessments that do occur have inadequate scope. In those assessed, the prevalence of hypopituitarism is high, with multiple hormones affected in some. This may reflect selection bias, if testing is based on clinical suspicion. Given this high prevalence, we recommend the development of screening tools for early detection of pituitary dysfunction following TBI. The relevance of early testing will be discussed.

U2 - 10.1016/j.ijsu.2014.07.244

DO - 10.1016/j.ijsu.2014.07.244

M3 - Abstract

VL - 12

SP - S53

JO - International journal of surgery (London, England)

JF - International journal of surgery (London, England)

SN - 1743-9191

IS - supplement 3

ER -