The Prevalence and Phenomenology of Repetitive Behavior in Genetic Syndromes

Research output: Contribution to journalArticle

Authors

Colleges, School and Institutes

Abstract

We investigated the prevalence and phenomenology of repetitive behavior in genetic syndromes to detail profiles of behavior. The Repetitive Behaviour Questionnaire (RBQ) provides fine-grained identification of repetitive behaviors. The RBQ was employed to examine repetitive behavior in Angelman (N = 104), Cornelia de Lange (N = 101), Cri-du-Chat (N = 58), Fragile X (N = 191), Prader-Willi (N = 189), Lowe (N = 56) and Smith-Magenis (N = 42) syndromes and individuals with intellectual disability of heterogeneous aetiology (N = 56). Repetitive behavior was variable across syndromes. Fragile X syndrome scored highly on all subscales. Angelman syndrome demonstrated a significantly lowered probability for most behaviors. Prader-Willi, Cri-du-Chat and Smith-Magenis syndrome evidenced unique profiles of repetitive behavior. There is extreme heterogeneity of repetitive behavior across genetic syndromes, highlighting syndrome specific profiles.

Details

Original languageEnglish
Pages (from-to)572-588
JournalJournal of Autism and Developmental Disorders
Volume39
Issue number4
Publication statusPublished - 27 Nov 2008

Keywords

  • Compulsive behavior, Behavioral phenotype, Repetitive behavior, Autism spectrum disorder, Stereotyped behavior