The pH Induced Vesicle to Micelle Morphology Transition of a THP-Protected Polymer

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Colleges, School and Institutes


A diblock copolymer consisting of tetrahydropyranyl acrylate (THPA) as a pH‐deprotectable block, and a permanently hydrophobic block, methyl acrylate, was synthesized by RAFT polymerization using a quaternary amine functionalized, hydrophilic, RAFT chain transfer agent. The polymer self‐assembled in water to form vesicles with Dh = 130 nm, as determined by DLS and cryogenic transmission electron microscopy. Acid catalyzed deprotection of the THPA units to yield acrylic acid resulted in a vesicle to micelle morphology transition, as evidenced by the decrease in hydrodynamic diameter to Dh = 19 nm and the observation of micelles by dry state transmission electron microscopy. © 2014 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2014, 52, 3026–3031


Original languageEnglish
Pages (from-to)3026-3031
Number of pages6
JournalJournal of Polymer Science Part a-Polymer Chemistry
Issue number21
Publication statusPublished - 16 Aug 2014


  • diblock, copolymer, micelle, morphology, pH-responsive, RAFT, transition, vesicle