The persistence of self-injurious and aggressive behavior in males with fragile X syndrome over 8 years: a longitudinal study of prevalence and predictive risk markers

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@article{cd4f3a603cd844dbaef27da7c54d133b,
title = "The persistence of self-injurious and aggressive behavior in males with fragile X syndrome over 8 years: a longitudinal study of prevalence and predictive risk markers",
abstract = "Self-injurious and aggressive behaviors are common in fragile X syndrome (FXS). However, little is known about the persistence of these behaviors and associated risk markers. We established the prevalence and persistence of self-injurious and aggressive behaviors over eight years in males with FXS, and associations with risk markers. Results showed 77{\%} and 69{\%} persistence rates for self-injurious and aggressive behavior, respectively. Baseline levels of repetitive behavior predicted persistent self-injurious behavior. Chronological age, impulsivity and overactivity were associated with persistent aggressive behavior but only impulsivity predicted persistence. This is the first study to document the persistence of self-injurious and aggressive behavior in FXS over the medium to long term and to identify behavioral risk markers that might facilitate targeted early intervention.",
keywords = "Aggression, Autism, Challenging behavior, Early intervention, Fragile X syndrome, Impulsivity, Repetitive behavior, Risk markers, Self-injurious behavior",
author = "Hayley Crawford and Efthalia Karakatsani and Gursharan Singla and Chris Oliver",
year = "2019",
month = "4",
day = "24",
doi = "10.1007/s10803-019-04002-3",
language = "English",
journal = "Journal of Autism and Developmental Disorders",
issn = "0162-3257",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - The persistence of self-injurious and aggressive behavior in males with fragile X syndrome over 8 years

T2 - a longitudinal study of prevalence and predictive risk markers

AU - Crawford, Hayley

AU - Karakatsani, Efthalia

AU - Singla, Gursharan

AU - Oliver, Chris

PY - 2019/4/24

Y1 - 2019/4/24

N2 - Self-injurious and aggressive behaviors are common in fragile X syndrome (FXS). However, little is known about the persistence of these behaviors and associated risk markers. We established the prevalence and persistence of self-injurious and aggressive behaviors over eight years in males with FXS, and associations with risk markers. Results showed 77% and 69% persistence rates for self-injurious and aggressive behavior, respectively. Baseline levels of repetitive behavior predicted persistent self-injurious behavior. Chronological age, impulsivity and overactivity were associated with persistent aggressive behavior but only impulsivity predicted persistence. This is the first study to document the persistence of self-injurious and aggressive behavior in FXS over the medium to long term and to identify behavioral risk markers that might facilitate targeted early intervention.

AB - Self-injurious and aggressive behaviors are common in fragile X syndrome (FXS). However, little is known about the persistence of these behaviors and associated risk markers. We established the prevalence and persistence of self-injurious and aggressive behaviors over eight years in males with FXS, and associations with risk markers. Results showed 77% and 69% persistence rates for self-injurious and aggressive behavior, respectively. Baseline levels of repetitive behavior predicted persistent self-injurious behavior. Chronological age, impulsivity and overactivity were associated with persistent aggressive behavior but only impulsivity predicted persistence. This is the first study to document the persistence of self-injurious and aggressive behavior in FXS over the medium to long term and to identify behavioral risk markers that might facilitate targeted early intervention.

KW - Aggression

KW - Autism

KW - Challenging behavior

KW - Early intervention

KW - Fragile X syndrome

KW - Impulsivity

KW - Repetitive behavior

KW - Risk markers

KW - Self-injurious behavior

UR - http://www.scopus.com/inward/record.url?scp=85064752463&partnerID=8YFLogxK

U2 - 10.1007/s10803-019-04002-3

DO - 10.1007/s10803-019-04002-3

M3 - Article

JO - Journal of Autism and Developmental Disorders

JF - Journal of Autism and Developmental Disorders

SN - 0162-3257

ER -