The periodontal health component of the Renal Impairment In Secondary Care (RIISC) cohort study: a description of the rationale, methodology and initial baseline results

Research output: Contribution to journalArticlepeer-review


  • Amneet Sidhu
  • Viren Vithlani
  • Mutahir Rahman
  • Stephanie Stringer
  • Mark Jesky
  • Okdeep Kaur
  • Charles Ferro

Colleges, School and Institutes


INTRODUCTION: Chronic kidney disease (CKD) is associated with significant morbidity and mortality. There is a need to identify novel and modifiable risk factors in such patients. The periodontal component of the Renal Impairment In Secondary Care (RIISC) study aims to evaluate the association between chronic periodontitis and CKD progression.

METHODS: The RIISC study is a prospective, observational cohort study of patients with CKD from a renal clinic at a hospital in the West Midlands region of the UK. Patients undergo a periodontal examination and plaque and saliva sampling. To benchmark the oral health status of the RIISC cohort, we compared it to the Adult Dental Health Survey 2009 (ADHS), a representative survey of the oral health of community dwelling adults in the UK.

RESULTS: Of the first 500 patients recruited into the RIISC study, 469 patients underwent a dental examination and 80 (17%) were edentulous. Among dentate subjects, patients within RIISC were significantly more likely to have any (OR 4.0 95% CI 2.7-5.9) or severe (OR 3.8 95% CI 2.5-5.6) periodontitis compared to the ADHS sample.

CONCLUSION: The prevalence and severity of chronic periodontitis in this cohort of CKD patients is markedly higher than a geographically matched control population.

Bibliographic note

© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.


Original languageEnglish
Pages (from-to)653-61
Number of pages9
JournalJournal of Clinical Periodontology
Issue number7
Early online date30 Jun 2014
Publication statusPublished - Jul 2014


  • Adult, Aged, Aged, 80 and over, Case-Control Studies, Chronic Periodontitis, Cohort Studies, Dental Plaque, Dental Plaque Index, England, Female, Health Status, Humans, Male, Middle Aged, Mouth, Edentulous, Oral Health, Periodontal Attachment Loss, Periodontal Index, Periodontal Pocket, Prevalence, Prospective Studies, Renal Insufficiency, Chronic, Saliva, Vulnerable Populations, Young Adult