The Pco proteins are involved in periplasmic copper handling in Escherichia coli

Research output: Contribution to journalArticle


  • SM Lee
  • G Grass
  • C Rensing
  • SR Barrett
  • CJD Yates
  • Jivko Stoyanov

Colleges, School and Institutes


The interactions between the plasmid-borne copper resistance determinant, pco, and the main copper export system in Escherichia coli have been investigated and no direct interaction has been found. The PcoE and PcoC proteins are periplasmic and PcoC binds one Cu ion per protein molecule. PcoA is also periplasmic and can substitute for the chromosomally encoded CueO protein. The pco determinant is proposed to exert its effect through periplasmic handling of excess copper ions and to increase the level of resistance to copper ions above that conferred by copA alone.


Original languageEnglish
Pages (from-to)616-620
Number of pages5
JournalBiochemical and Biophysical Research Communications
Issue number3
Publication statusPublished - 19 Jul 2002


  • Cu(II), metal homeostasis, copper resistance, cop, TAT