The P2X7 receptor gene polymorphism 1513 A to C has no effect on clinical prognostic markers and survival in multiple myeloma

S Paneesha, J Starczynski, C Pepper, J Delgado, L Hooper, C Fegan, Guy Pratt

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A P2X7 receptor gene polymorphism 1513 A-->C has recently been suggested as playing a role in the pathogenesis and disease progression of chronic lymphocytic leukemia, although several studies have failed to show any effect of the polymorphism. The effects of this polymorphism were analysed in 136 patients with multiple myeloma. The frequency of the polymorphism in the myeloma samples was not significantly different from that found in normal healthy controls. There was no significant difference in age at diagnosis, creatinine, hemoglobin, beta-2 microglobulin, immunoglobulin sub-type, duration of first response and overall survival. These results are in keeping with findings in a cohort of 121 chronic lymphocytic leukemia and do not support a role for this polymorphism in multiple myeloma.
Original languageEnglish
Pages (from-to)281-284
Number of pages4
JournalLeukemia and Lymphoma
Volume47
DOIs
Publication statusPublished - 1 Feb 2006

Keywords

  • polymorphism
  • multiple myeloma
  • P2X7

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