The necessity of animal models in pain research

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The necessity of animal models in pain research. / Mogil, JS; Davis, KD; Derbyshire, Stuart.

In: Pain, Vol. 151, No. 1, 01.10.2010, p. 12-17.

Research output: Contribution to journalReview article

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Mogil, JS ; Davis, KD ; Derbyshire, Stuart. / The necessity of animal models in pain research. In: Pain. 2010 ; Vol. 151, No. 1. pp. 12-17.

Bibtex

@article{ba34b74799804d13ab8d475e775f96c9,
title = "The necessity of animal models in pain research",
abstract = "There exists currently a fair degree of introspection in the pain research community about the value of animal research. This review represents a defense of animal research in pain. We discuss the inherent advantage of animal models over human research as well as the crucial complementary roles animal studies play vis-a-vis human imaging and genetic studies. Finally, we discuss recent developments in animal models of pain that should improve the relevance and translatability of findings using laboratory animals. We believe that pain research using animal models is a continuing necessity-to understand fundamental mechanisms, identify new analgesic targets, and inform, guide and follow up human studies-if novel analgesics are to be developed for the treatment of chronic pain. (C) 2010 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.",
author = "JS Mogil and KD Davis and Stuart Derbyshire",
year = "2010",
month = oct
day = "1",
doi = "10.1016/j.pain.2010.07.015",
language = "English",
volume = "151",
pages = "12--17",
journal = "Pain",
issn = "0304-3959",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

RIS

TY - JOUR

T1 - The necessity of animal models in pain research

AU - Mogil, JS

AU - Davis, KD

AU - Derbyshire, Stuart

PY - 2010/10/1

Y1 - 2010/10/1

N2 - There exists currently a fair degree of introspection in the pain research community about the value of animal research. This review represents a defense of animal research in pain. We discuss the inherent advantage of animal models over human research as well as the crucial complementary roles animal studies play vis-a-vis human imaging and genetic studies. Finally, we discuss recent developments in animal models of pain that should improve the relevance and translatability of findings using laboratory animals. We believe that pain research using animal models is a continuing necessity-to understand fundamental mechanisms, identify new analgesic targets, and inform, guide and follow up human studies-if novel analgesics are to be developed for the treatment of chronic pain. (C) 2010 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

AB - There exists currently a fair degree of introspection in the pain research community about the value of animal research. This review represents a defense of animal research in pain. We discuss the inherent advantage of animal models over human research as well as the crucial complementary roles animal studies play vis-a-vis human imaging and genetic studies. Finally, we discuss recent developments in animal models of pain that should improve the relevance and translatability of findings using laboratory animals. We believe that pain research using animal models is a continuing necessity-to understand fundamental mechanisms, identify new analgesic targets, and inform, guide and follow up human studies-if novel analgesics are to be developed for the treatment of chronic pain. (C) 2010 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

U2 - 10.1016/j.pain.2010.07.015

DO - 10.1016/j.pain.2010.07.015

M3 - Review article

C2 - 20696526

VL - 151

SP - 12

EP - 17

JO - Pain

JF - Pain

SN - 0304-3959

IS - 1

ER -