The natural history of, and risk factors for, progressive Chronic Kidney Disease (CKD): the Renal Impairment in Secondary care (RIISC) study; rationale and protocol

Research output: Contribution to journalArticlepeer-review


  • Stephanie Stringer
  • Mary Dutton
  • Mark Jesky
  • Khai Ng
  • Okdeep Kaur
  • Charles Ferro


Chronic kidney disease (CKD) affects up to 16% of the adult population and is associated with significant morbidity and mortality. People at highest risk from progressive CKD are defined by a sustained decline in estimated glomerular filtration rate (eGFR) and/or the presence of significant albuminuria/proteinuria and/or more advanced CKD. Accurate mapping of the bio-clinical determinants of this group will enable improved risk stratification and direct the development of better targeted management for people with CKD.


Original languageEnglish
Article number95
JournalBMC Nephrology
Publication statusPublished - 25 Apr 2013