The Multi-Center Randomized Controlled Trial (RCT) Published by the Journal of the American Medical Association (JAMA) on the Effect of Periodontal Therapy on Glycated Hemoglobin (HbA1c) Has Fundamental Problems

Wenche S Borgnakke, Iain L C Chapple, Robert J Genco, Gary Armitage, P Mark Bartold, Francesco D'Aiuto, Paul I Eke, William V Giannobile, Thomas Kocher, Kenneth S Kornman, Niklaus P Lang, Phoebus N Madianos, Shinya Murakami, Fusanori Nishimura, Steven Offenbacher, Philip M Preshaw, Amin Ur Rahman, Mariano Sanz, Jørgen Slots, Maurizio S TonettiThomas E Van Dyke

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Abstract

ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: The effect of nonsurgical periodontal therapy on hemoglobin A1c levels in persons with type 2 diabetes and chronic periodontitis: a randomized clinical trial. Engebretson SP, Hyman LG, Michalowicz BS, Schoenfeld ER, Gelato MC, Hou W, et al (16 authors). JAMA 2013;310(23):2523-32.

REVIEWERS: Wenche S. Borgnakke, Iain L. C. Chapple, Robert J. Genco, Gary Armitage, P. Mark Bartold, Francesco D'Aiuto, Paul I. Eke, William V. Giannobile, Thomas Kocher, Kenneth S. Kornman, Niklaus P. Lang, Phoebus N. Madianos, Shinya Murakami, Fusanori Nishimura, Steven Offenbacher, Philip M. Preshaw, Amin ur Rahman, Mariano Sanz, Jørgen Slots, Maurizio S. Tonetti, Thomas E. Van Dyke

PURPOSE/QUESTION: Does non-surgical periodontal treatment reduce levels of HbA1c in persons with type 2 diabetes and moderate to advanced chronic periodontitis?

SOURCE OF FUNDING: US Government - National Institute of Dental and Craniofacial Research, National Institutes of Health: Cooperative agreements ($15.4M): 1) UO1 DE018902 (Dr. Engebretson: $11.1M) and 2) U01 DE018886 (Dr. Hyman: $4.3M) TYPE OF STUDY/DESIGN: Multi-center RCT.

TRIAL REGISTRATION: clinicaltrials.gov identifier: NCT00997178.

LEVEL OF EVIDENCE: Level 2: Limited-quality, patient-oriented evidence

STRENGTH OF RECOMMENDATION GRADE: Not applicable.

Original languageEnglish
Pages (from-to)127-32
Number of pages6
JournalJournal of Evidence Based Dental Practice
Volume14
Issue number3
DOIs
Publication statusPublished - Sept 2014

Bibliographical note

Copyright © 2014 Elsevier Inc. All rights reserved.

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