The mesenchymal stem cell marker CD248 (endosialin) is a negative regulator of bone formation in mice
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CD248 (tumor endothelial marker 1/endosialin) is found on stromal cells and is highly expressed during malignancy and inflammation. Studies have shown a reduction in inflammatory arthritis in CD248-knockout (CD248(-/-) ) mice. The aim of the present study was to investigate the functional effect of genetic deletion of CD248 on bone mass.
|Number of pages||10|
|Journal||Arthritis & Rheumatism|
|Publication status||Published - 27 Sep 2012|