The mesenchymal stem cell marker CD248 (endosialin) is a negative regulator of bone formation in mice

Research output: Contribution to journalArticlepeer-review


  • Eman Azzam
  • Callum Poyser
  • Jeremy S Duffield
  • David L Huso
  • Steffen Gay
  • Caroline Ospelt
  • Clare Isacke
  • Simon R Goodyear
  • Michael J Rogers


CD248 (tumor endothelial marker 1/endosialin) is found on stromal cells and is highly expressed during malignancy and inflammation. Studies have shown a reduction in inflammatory arthritis in CD248-knockout (CD248(-/-) ) mice. The aim of the present study was to investigate the functional effect of genetic deletion of CD248 on bone mass.


Original languageEnglish
Pages (from-to)3334-3343
Number of pages10
JournalArthritis & Rheumatism
Issue number10
Publication statusPublished - 27 Sep 2012