The Menstrual Cycle and Drug Metabolism

Research output: Contribution to journalArticle

Standard

The Menstrual Cycle and Drug Metabolism. / Mitchell, SC; Smith, RL; Waring, Rosemary.

In: Current Drug Metabolism, Vol. 10, No. 5, 01.06.2009, p. 499-507.

Research output: Contribution to journalArticle

Harvard

APA

Vancouver

Author

Mitchell, SC ; Smith, RL ; Waring, Rosemary. / The Menstrual Cycle and Drug Metabolism. In: Current Drug Metabolism. 2009 ; Vol. 10, No. 5. pp. 499-507.

Bibtex

@article{71de9d400f0c4d5dbce59bdf0a7fd23e,
title = "The Menstrual Cycle and Drug Metabolism",
abstract = "Within the field of drug metabolism, when addressing quantitative aspects, an average value is traditionally quoted, commonly the arithmetic mean with perhaps an indication of spread. Better still a range of values may be given, thereby acknowledging that various factors may precipitate differences between individuals. A single subject, however, usually only merits a single value. Nevertheless, events such as an acute illness or concurrent drug therapy serve to alert that this value may change substantially over a relatively short time-period, although any potential effects of naturally occurring phenomena, such as the female menstrual cycle, are often overlooked or disregarded. Are the biochemical and physiological changes that occur during the menstrual cycle able to influence xenobiotic metabolism? Is the idea of a stable and unwavering baseline within a single healthy individual flawed? Is it time to reassess our thinking with regards to such aspects? This brief review explores these issues and examines information available within the literature for evidence of potential influences of menstrual cycle events upon drug metabolism, defined as the actual chemical alteration of the parent molecule into another chemical species.",
author = "SC Mitchell and RL Smith and Rosemary Waring",
year = "2009",
month = jun,
day = "1",
doi = "10.2174/138920009788897966",
language = "English",
volume = "10",
pages = "499--507",
journal = "Current Drug Metabolism",
issn = "1389-2002",
publisher = "Bentham Science Publishers",
number = "5",

}

RIS

TY - JOUR

T1 - The Menstrual Cycle and Drug Metabolism

AU - Mitchell, SC

AU - Smith, RL

AU - Waring, Rosemary

PY - 2009/6/1

Y1 - 2009/6/1

N2 - Within the field of drug metabolism, when addressing quantitative aspects, an average value is traditionally quoted, commonly the arithmetic mean with perhaps an indication of spread. Better still a range of values may be given, thereby acknowledging that various factors may precipitate differences between individuals. A single subject, however, usually only merits a single value. Nevertheless, events such as an acute illness or concurrent drug therapy serve to alert that this value may change substantially over a relatively short time-period, although any potential effects of naturally occurring phenomena, such as the female menstrual cycle, are often overlooked or disregarded. Are the biochemical and physiological changes that occur during the menstrual cycle able to influence xenobiotic metabolism? Is the idea of a stable and unwavering baseline within a single healthy individual flawed? Is it time to reassess our thinking with regards to such aspects? This brief review explores these issues and examines information available within the literature for evidence of potential influences of menstrual cycle events upon drug metabolism, defined as the actual chemical alteration of the parent molecule into another chemical species.

AB - Within the field of drug metabolism, when addressing quantitative aspects, an average value is traditionally quoted, commonly the arithmetic mean with perhaps an indication of spread. Better still a range of values may be given, thereby acknowledging that various factors may precipitate differences between individuals. A single subject, however, usually only merits a single value. Nevertheless, events such as an acute illness or concurrent drug therapy serve to alert that this value may change substantially over a relatively short time-period, although any potential effects of naturally occurring phenomena, such as the female menstrual cycle, are often overlooked or disregarded. Are the biochemical and physiological changes that occur during the menstrual cycle able to influence xenobiotic metabolism? Is the idea of a stable and unwavering baseline within a single healthy individual flawed? Is it time to reassess our thinking with regards to such aspects? This brief review explores these issues and examines information available within the literature for evidence of potential influences of menstrual cycle events upon drug metabolism, defined as the actual chemical alteration of the parent molecule into another chemical species.

U2 - 10.2174/138920009788897966

DO - 10.2174/138920009788897966

M3 - Article

C2 - 19689246

VL - 10

SP - 499

EP - 507

JO - Current Drug Metabolism

JF - Current Drug Metabolism

SN - 1389-2002

IS - 5

ER -